ZFIN Morpholino: MO4-tal1

Target Location

Genome Build: GRCz11Chromosome: 22

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO4-tal1

No data available

Phenotype

Phenotype resulting from MO4-tal1

Phenotype	Fish	Figures
blood vasculature lacks parts or has fewer parts of type blood vessel, abnormal	s843Tg + MO4-tal1	Fig. S5 from Reischauer et al., 2016
caudal vein plexus EGFP expression decreased amount, abnormal	s843Tg + MO4-tal1	Fig. S5 from Reischauer et al., 2016
embryonic hemopoiesis disrupted, abnormal	AB + MO4-tal1	Fig. 4 from Liu et al., 2008
endocardium spi1b expression increased amount, abnormal	WT + MO4-tal1	Fig. 4 from Capon et al., 2022
endocardium EGFP expression increased amount, abnormal	WT + MO4-tal1	Fig. 4 from Capon et al., 2022

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Phenotype of all Fish created by or utilizing MO4-tal1

Phenotype	Fish	Conditions	Figures
posterior lateral mesoderm morphology, abnormal	AB + MO4-tal1	standard conditions	Fig. 4 from Liu et al., 2008
embryonic hemopoiesis disrupted, abnormal	AB + MO4-tal1	standard conditions	Fig. 4 from Liu et al., 2008
endocardium myl7 expression spatial pattern, abnormal	WT + MO4-tal1	standard conditions	Fig. 4 from Capon et al., 2022
endocardium EGFP expression spatial pattern, abnormal	WT + MO4-tal1	standard conditions	Fig. 4 from Capon et al., 2022
myeloid cell absent, abnormal	WT + MO4-tal1	standard conditions	Fig. S6 from Hall et al., 2007

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Citations

Include unpublished citations

Capon, S.J., Uribe, V., Dominado, N., Ehrlich, O., Smith, K.A. (2022) Endocardial identity is established during early somitogenesis by Bmp signalling acting upstream of npas4l and etv2. Development (Cambridge, England). 149(9):
Metikala, S., Warkala, M., Casie Chetty, S., Chestnut, B., Rufin Florat, D., Plender, E., Nester, O., Koenig, A.L., Astrof, S., Sumanas, S. (2022) Integration of vascular progenitors into functional blood vessels represents a distinct mechanism of vascular growth. Developmental Cell. 57(6):767-782.e6
Chestnut, B., Casie Chetty, S., Koenig, A.L., Sumanas, S. (2020) Single-cell transcriptomic analysis identifies the conversion of zebrafish Etv2-deficient vascular progenitors into skeletal muscle. Nature communications. 11:2796
Yin, H.M., Yan, L.F., Liu, Q., Peng, Z., Zhang, C.Y., Xia, Y., Su, D., Gu, A.H., Zhou, Y. (2020) Activating transcription factor 3 coordinates differentiation of cardiac and hematopoietic progenitors by regulating glucose metabolism. Science advances. 6:eaay9466
Reischauer, S., Stone, O.A., Villasenor, A., Chi, N., Jin, S.W., Martin, M., Lee, M.T., Fukuda, N., Marass, M., Witty, A., Fiddes, I., Kuo, T., Chung, W.S., Salek, S., Lerrigo, R., Alsiö, J., Luo, S., Tworus, D., Augustine, S.M., Mucenieks, S., Nystedt, B., Giraldez, A.J., Schroth, G.P., Andersson, O., Stainier, D.Y. (2016) Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification. Nature. 535:294-8
Hasegawa, T., Nakajima, T., Ishida, T., Kudo, A., Kawakami, A. (2015) A diffusible signal derived from hematopoietic cells supports the survival and proliferation of regenerative cells during zebrafish fin fold regeneration. Developmental Biology. 399(1):80-90
Glenn, N.O., Schumacher, J.A., Kim, H.J., Zhao, E.J., Skerniskyte, J., Sumanas, S. (2014) Distinct regulation of the anterior and posterior myeloperoxidase expression by Etv2 and Gata1 during primitive Granulopoiesis in zebrafish. Developmental Biology. 393(1):149-59
Schupp, M.O., Waas, M., Chun, C.Z., Ramchandran, R. (2014) Transcriptional inhibition of etv2 expression is essential for embryonic cardiac development. Developmental Biology. 393(1):71-83
Simões, F.C., Peterkin, T., and Patient, R. (2011) Fgf differentially controls cross-antagonism between cardiac and haemangioblast regulators. Development (Cambridge, England). 138(15):3235-3245
Ren, X., Gomez, G.A., Zhang, B., and Lin, S. (2010) Scl isoforms act downstream of etsrp to specify angioblasts and definitive hematopoietic stem cells. Blood. 115(26):5338-5346

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