Gene

tal1

ID
ZDB-GENE-980526-501
Name
T-cell acute lymphocytic leukemia 1
Symbol
tal1 Nomenclature History
Previous Names
  • tal-1
  • scl/tal1
  • scl
  • zgc:85605 (1)
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Enables sequence-specific DNA binding activity. Involved in circulatory system development and hemopoiesis. Acts upstream of or within several processes, including circulatory system development; hemopoiesis; and positive regulation of endothelial cell differentiation. Predicted to be located in nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; hematopoietic cell; hematopoietic system; and mesoderm. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human TAL1 (TAL bHLH transcription factor 1, erythroid differentiation factor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
363 figures from 234 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
26 figures from 10 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
bns497Allele with multiple variantsUnknownUnknownCRISPR
bns498Allele with one deletionExon 4UnknownCRISPR
t21384Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-tal1Mattonet et al., 2022
MO1-tal1N/A (8)
MO2-tal1N/A (6)
MO3-tal1N/A (2)
MO4-tal1N/A (21)
MO5-tal1N/A (4)
MO6-tal1N/A (4)
MO7-tal1N/A (6)
MO8-tal1N/A (4)
MO9-tal1N/AQian et al., 2007
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Human Disease
Associated With tal1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acute lymphoblastic leukemia Alliance Leukemia, T-cell acute lymphocytic, somatic 613065
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Associated With tal1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Family IPR040238 Helix-loop-helix protein TAL-like
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
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Domain Details Per Protein
Protein Additional Resources Length Helix-loop-helix DNA-binding domain superfamily Helix-loop-helix protein TAL-like Myc-type, basic helix-loop-helix (bHLH) domain
UniProtKB:O93507 InterPro 324
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 22
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA ottdart00000001376 (1) Havana 2,510 nt
mRNA tal1-201 (1) Ensembl 2,643 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg2(-5.0tal1:EGFP)
  • tal1
  • Danio rerio
1 (2)
Tg(-5.0tal1:EGFP)
  • tal1
  • Danio rerio
2 (7)
Tg(-6tal1:EGFP)
  • tal1
  • Danio rerio
1 (8)
Tg(fli1:LOXP-RFP-LOXP-dntal1)
  • Danio rerio
1Rolland et al., 2022
TgPAC(tal1:d2EGFP)
  • tal1
  • Danio rerio
1 (5)
TgPAC(tal1:d2EGFP,tal1:DsRed)
  • tal1
  • Danio rerio
1 (3)
TgPAC(tal1:DsRed)
  • tal1
  • Danio rerio
1 (7)
TgPAC(tal1:EGFP)
  • tal1
  • Danio rerio
1 (3)
Tg(tal1:atf3-2A-EGFP)
  • tal1
  • Danio rerio
1Yin et al., 2020
Tg(tal1:GFP)
  • tal1
  • Danio rerio
1Mizoguchi et al., 2020
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-135J1ZFIN Curated Data
Contained inBACDKEY-38N4ZFIN Curated Data
Contained inPACBUSM1-129I22ZFIN Curated Data
EncodescDNAMGC:85605
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanTAL11
Conserved genome location (synteny) (2)
Amino acid sequence comparison (4)
MouseTal14
Coincident expression (2)
Conserved genome location (synteny) (1)
Amino acid sequence comparison (3)
Citations
1 - 10 of 432
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