Gene
tal1
- ID
- ZDB-GENE-980526-501
- Name
- T-cell acute lymphocytic leukemia 1
- Symbol
- tal1 Nomenclature History
- Previous Names
-
- tal-1
- scl/tal1
- scl
- zgc:85605 (1)
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Enables sequence-specific DNA binding activity. Involved in definitive hemopoiesis; endocardium formation; and myeloid cell differentiation. Acts upstream of or within several processes, including animal organ development; circulatory system development; and positive regulation of endothelial cell differentiation. Predicted to be located in nucleus. Is expressed in several structures, including cardiovascular system; hematopoietic cell; hematopoietic system; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human TAL1 (TAL bHLH transcription factor 1, erythroid differentiation factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 328 figures from 214 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85605 (25 images)
Wild Type Expression Summary
- All Phenotype Data
- 25 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute lymphoblastic leukemia | Alliance | Leukemia, T-cell acute lymphocytic, somatic | 613065 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Helix-loop-helix DNA-binding domain superfamily | Helix-loop-helix protein TAL-like | Myc-type, basic helix-loop-helix (bHLH) domain |
|---|---|---|---|---|
|
UniProtKB:O93507
|
324 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA | ottdart00000001376 (1) | 2510 nt | |
| mRNA |
tal1-201
(1)
|
2643 nt |
Interactions and Pathways
No data available
Plasmids
No data available