Gene
tal1
- ID
- ZDB-GENE-980526-501
- Name
- T-cell acute lymphocytic leukemia 1
- Symbol
- tal1 Nomenclature History
- Previous Names
-
- tal-1
- scl/tal1
- scl
- zgc:85605 (1)
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Enables sequence-specific DNA binding activity. Involved in circulatory system development and hemopoiesis. Acts upstream of or within several processes, including circulatory system development; hemopoiesis; and positive regulation of endothelial cell differentiation. Predicted to be located in nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; hematopoietic cell; hematopoietic system; and mesoderm. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human TAL1 (TAL bHLH transcription factor 1, erythroid differentiation factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 363 figures from 234 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85605 (25 images)
Wild Type Expression Summary
- All Phenotype Data
- 26 figures from 10 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
acute lymphoblastic leukemia | Alliance | Leukemia, T-cell acute lymphocytic, somatic | 613065 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Helix-loop-helix DNA-binding domain superfamily | Helix-loop-helix protein TAL-like | Myc-type, basic helix-loop-helix (bHLH) domain |
---|---|---|---|---|---|
UniProtKB:O93507 | InterPro | 324 |
1 - 1 of 1
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA | ottdart00000001376 (1) | Havana | 2,510 nt | ||
mRNA |
tal1-201
(1)
|
Ensembl | 2,643 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg2(-5.0tal1:EGFP) |
|
| 1 | (2) | |
Tg(-5.0tal1:EGFP) |
|
| 2 | (7) | |
Tg(-6tal1:EGFP) |
|
| 1 | (8) | |
Tg(fli1:LOXP-RFP-LOXP-dntal1) |
| 1 | Rolland et al., 2022 | ||
TgPAC(tal1:d2EGFP) |
|
| 1 | (5) | |
TgPAC(tal1:d2EGFP,tal1:DsRed) |
|
| 1 | (3) | |
TgPAC(tal1:DsRed) |
|
| 1 | (7) | |
TgPAC(tal1:EGFP) |
|
| 1 | (3) | |
Tg(tal1:atf3-2A-EGFP) |
|
| 1 | Yin et al., 2020 | |
Tg(tal1:GFP) |
|
| 1 | Mizoguchi et al., 2020 |
1 - 10 of 12
Show
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-135J1 | ZFIN Curated Data | |
Contained in | BAC | DKEY-38N4 | ZFIN Curated Data | |
Contained in | PAC | BUSM1-129I22 | ZFIN Curated Data | |
Encodes | cDNA | MGC:85605 |
1 - 4 of 4
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_213237 (1) | 2655 nt | ||
Genomic | GenBank:BX322568 (2) | 134716 nt | ||
Polypeptide | UniProtKB:O93507 (1) | 324 aa |
- Laverde, V., Loges, L., Sumanas, S. (2025) Zebrafish ETS transcription factor Fli1b functions upstream of Scl/Tal1 during embryonic hematopoiesis. Biology Open. :
- Liu, M., Li, Y., Deng, Z., Zhang, K., Huang, S., Xia, J., Feng, Y., Liang, Y., Sun, C., Liu, X., Li, S., Su, B., Dong, Y., Huang, S. (2025) Mcm5 mutation leads to silencing of Stat1-bcl2 which accelerating apoptosis of immature T lymphocytes with DNA damage. Cell Death & Disease. 16:8484
- Ter Horst, S., Siekierska, A., De Meulemeester, A.S., Cuvry, A., Cools, L., Neyts, J., de Witte, P., Rocha-Pereira, J. (2025) The Dissemination of Rift Valley Fever Virus to the Eye and Sensory Neurons of Zebrafish Larvae Is Stat1-Dependent. Viruses. 17:
- Yang, S., Zhang, X., Li, X., Li, H. (2025) Crip2 affects vascular development by fine-tuning endothelial cell aggregation and proliferation. Cellular and molecular life sciences : CMLS. 82:110110
- Zhou, W., Cai, W., Li, Y., Gao, L., Liu, X., Liu, S., Lei, J., Zhang, J., Wang, Y., Jiang, Z., Wu, X., Fan, X., Li, F., Zheng, L., Yuan, W. (2025) The Interaction Between the asb5a and asb5b Subtypes Jointly Regulates the L-R Asymmetrical Development of the Heart in Zebrafish. International Journal of Molecular Sciences. 26:
- Brix, A., Belleri, L., Pezzotta, A., Pettinato, E., Mazzola, M., Zoccolillo, M., Marozzi, A., Monteiro, R., Del Bene, F., Mortellaro, A., Pistocchi, A. (2024) ADA2 regulates inflammation and hematopoietic stem cell emergence via the A2bR pathway in zebrafish. Communications biology. 7:615615
- Dong, Y., Yang, Y., Wang, H., Feng, D., Nist, E., Yapundich, N., Spurlock, B., Craft, M., Qian, L., Liu, J. (2024) Single-cell chromatin profiling reveals genetic programs activating proregenerative states in nonmyocyte cells. Science advances. 10:eadk4694
- Han, X., He, W., Liang, D., Liu, X., Zhou, J., de Thé, H., Zhu, J., Yuan, H. (2024) Creg1 Regulates Erythroid Development via TGF-β/Smad2-Klf1 Axis in Zebrafish. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 11(33):e2402804
- Huang, W., Yue, Y., Hao, W., Zhang, Z., Cai, P., Yang, D. (2024) mTORC1 mediates the expansion of hematopoietic stem and progenitor cells through ribosome biogenesis protein Urb2 in zebrafish. Stem Cell Reports. 19(9):1277-1288
- Lawir, D.F., Soza-Ried, C., Iwanami, N., Siamishi, I., Bylund, G.O., O Meara, C., Sikora, K., Kanzler, B., Johansson, E., Schorpp, M., Cauchy, P., Boehm, T. (2024) Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish. Communications biology. 7:3131
1 - 10 of 432
Show