ZFIN Morpholino: MO1-clocka

Target Location

Genome Build: GRCz11Chromosome: 20

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-clocka

No data available

Phenotype

Phenotype resulting from MO1-clocka

Phenotype	Fish	Figures
angioblastic mesenchymal cell lmo2 expression decreased amount, abnormal	AB + MO1-clocka	Fig. 3 from Bian et al., 2017
angioblastic mesenchymal cell tal1 expression decreased amount, abnormal	AB + MO1-clocka	Fig. 3 from Bian et al., 2017
angioblastic mesenchymal cell fli1 expression decreased amount, abnormal	AB + MO1-clocka	Fig. 3 from Bian et al., 2017
axial mesoderm gsc expression decreased amount, abnormal	AB + MO1-clocka	Fig. 3 from Bian et al., 2017
axial mesoderm tbxta expression decreased amount, abnormal	AB + MO1-clocka	Fig. 3 from Bian et al., 2017

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Phenotype of all Fish created by or utilizing MO1-clocka

Phenotype	Fish	Conditions	Figures
axial mesoderm gsc expression decreased amount, abnormal	AB + MO1-clocka	standard conditions	Fig. 3 from Bian et al., 2017
whole organism clocka expression decreased amount, abnormal	AB + MO1-clocka	standard conditions	Fig. 2, Fig. 4 from Bian et al., 2017
whole organism ab4-smad labeling decreased amount, abnormal	AB + MO1-clocka	standard conditions	Fig. 4 from Bian et al., 2017
whole organism bhlhe40 expression decreased amount, abnormal	AB + MO1-clocka	standard conditions	Fig. 5 from Li et al., 2013
presumptive mesoderm eve1 expression decreased amount, abnormal	AB + MO1-clocka	standard conditions	Fig. 3 from Bian et al., 2017

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Citations

Include unpublished citations

Bian, S.S., Zheng, X.L., Sun, H.Q., Chen, J.H., Lu, Y.L., Liu, Y.Q., Tao, D.C., Ma, Y.X. (2017) Clock1a affects mesoderm development and primitive hematopoiesis by regulating Nodal-Smad3 signalings in the zebrafish embryo. The Journal of biological chemistry. 292(34):14165-14175
Li, Y., Li, G., Görling, B., Luy, B., Du, J., Yan, J. (2015) Integrative Analysis of Circadian Transcriptome and Metabolic Network Reveals the Role of De Novo Purine Synthesis in Circadian Control of Cell Cycle. PLoS Computational Biology. 11:e1004086
Li, Y., Li, G., Wang, H., Du, J., and Yan, J. (2013) Analysis of a gene regulatory cascade mediating circadian rhythm in zebrafish. PLoS Computational Biology. 9(2):e1002940
Li, P., Chaurasia, S.S., Gao, Y., Carr, A.L., Iuvone, P.M., and Li, L. (2008) CLOCK is required for maintaining the circadian rhythms of opsin mRNA expression in photoreceptor cells. The Journal of biological chemistry. 283(46):31673-31678
Triqueneaux, G., Thenot, S., Kakizawa, T., Antoch, M.P., Safi, R., Takahashi, J.S., Delaunay, F., and Laudet, V. (2004) The orphan receptor Rev-erb{alpha} gene is a target of the circadian clock pacemaker. Journal of molecular endocrinology. 33(3):585-608

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