Gene
clocka
- ID
- ZDB-GENE-990630-14
- Name
- clock circadian regulator a
- Symbol
- clocka Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Contributes to DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within photoperiodism; regulation of gene expression; and response to temperature stimulus. Part of CLOCK-BMAL transcription complex. Is active in chromatin. Is expressed in brain; head; ovary; and photoreceptor cell. Human ortholog(s) of this gene implicated in Alzheimer's disease and alcohol use disorder. Orthologous to human CLOCK (clock circadian regulator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000014 | PAS domain |
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR013767 | PAS fold |
| Family | IPR001067 | Nuclear translocator |
| Family | IPR047230 | Circadian locomoter output cycles protein kaput-like |
| Homologous_superfamily | IPR035965 | PAS domain superfamily |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
| Repeat | IPR001610 | PAC motif |
Domain Details Per Protein
| Protein | Additional Resources | Length | Circadian locomoter output cycles protein kaput-like | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Nuclear translocator | PAC motif | PAS domain | PAS domain superfamily | PAS fold |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5RIV1 | InterPro | 892 | ||||||||
| UniProtKB:A0A8M9PH45 | InterPro | 891 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| antisense |
ottdart00000059169
(1)
|
Ensembl | 3,722 nt | ||
| mRNA |
clocka-201
(1)
|
Ensembl | 3,424 nt | ||
| mRNA |
clocka-202
(1)
|
Ensembl | 6,535 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-clock | polyclonal | IgG | Goat |
|
Santa Cruz Biotechnology, Inc.
|
3 |
Plasmids
No data available