ZFIN Morpholino: MO1-wnt5b

Target Location

Genome Build: GRCz11Chromosome: 4

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-wnt5b

No data available

Phenotype

Phenotype resulting from MO1-wnt5b

Phenotype	Fish	Figures
anterior neural plate increased width, abnormal	WT + MO1-wnt5b	Fig. S7 from Castanon et al., 2013
axial chorda mesoderm decreased length, abnormal	WT + MO1-wnt5b	Fig. 8 from Goudevenou et al., 2011
axis decreased length, abnormal	WT + MO1-wnt5b	Fig. 6 from Goudevenou et al., 2011 Fig. 6 from Zhu et al., 2006
brain morphology, abnormal	WT + MO1-wnt5b	Fig. 6 , Fig. 8 from Goudevenou et al., 2011
caudal fin morphology, abnormal	WT + MO1-wnt5b	Figure 7. from Hung et al., 2020

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Phenotype of all Fish created by or utilizing MO1-wnt5b

Phenotype	Fish	Conditions	Figures
otolith deformed, abnormal	AB + MO1-wnt5b	standard conditions	Fig. 5 from Louwette et al., 2012
thrombocyte decreased amount, abnormal	AB + MO1-wnt5b	standard conditions	Fig. 5 from Louwette et al., 2012
posterior lateral line neuromast decreased amount, abnormal	AB + MO1-wnt5b	standard conditions	Fig. 5 from Louwette et al., 2012
convergent extension involved in gastrulation normal process quality, abnormal	AB/TU + MO1-wnt5b	standard conditions	Figure 5 from Saraswathy et al., 2022
notochord decreased length, abnormal	WT + MO1-wnt5b	standard conditions	Fig. S7 from Castanon et al., 2013 Fig. 6 from Zhu et al., 2006 Fig. 5 from Kilian et al., 2003

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Citations

Include unpublished citations

Saraswathy, V.M., Kurup, A.J., Sharma, P., Polès, S., Poulain, M., Fürthauer, M. (2022) The E3 Ubiquitin Ligase Mindbomb1 controls planar cell polarity-dependent convergent extension movements during zebrafish gastrulation. eLIFE. 11:
Castanon, I., Hannich, J.T., Abrami, L., Huber, F., Dubois, M., Müller, M., van der Goot, F.G., Gonzalez-Gaitan, M. (2020) Wnt-controlled sphingolipids modulate Anthrax Toxin Receptor palmitoylation to regulate oriented mitosis in zebrafish. Nature communications. 11:3317
Hung, I.C., Chen, T.M., Lin, J.P., Tai, Y.L., Shen, T.L., Lee, S.J. (2020) Wnt5b integrates Fak1a to mediate gastrulation cell movements via Rac1 and Cdc42. Open Biology. 10:190273
Zhang, J., Chandrasekaran, G., Li, W., Kim, D.Y., Jeong, I.Y., Lee, S.H., Liang, T., Bae, J.Y., Choi, I., Kang, H., Maeng, J.S., Kim, M.K., Lee, T., Park, S.W., Kim, M.J., Kim, H.S., Ro, H., Bae, Y.C., Park, H.C., Choi, E.Y., Choi, S.Y. (2020) Wnt-PLC-IP₃-Connexin-Ca²⁺ axis maintains ependymal motile cilia in zebrafish spinal cord. Nature communications. 11:1860
Gong, B., Shen, W., Xiao, W., Meng, Y., Meng, A., Jia, S. (2017) The Sec14-like phosphatidylinositol transfer proteins Sec14l3/SEC14L2 act as GTPase proteins to mediate Wnt/Ca²⁺ signaling.. eLIFE. 6
Nicenboim, J., Malkinson, G., Lupo, T., Asaf, L., Sela, Y., Mayseless, O., Gibbs-Bar, L., Senderovich, N., Hashimshony, T., Shin, M., Jerafi-Vider, A., Avraham-Davidi, I., Krupalnik, V., Hofi, R., Almog, G., Astin, J.W., Golani, O., Ben-Dor, S., Crosier, P.S., Herzog, W., Lawson, N.D., Hanna, J.H., Yanai, I., Yaniv, K. (2015) Lymphatic vessels arise from specialized angioblasts within a venous niche. Nature. 522(7554):56-61
Young, T., Poobalan, Y., Tan, E.K., Tao, S., Ong, S., Wehner, P., Schwenty-Lara, J., Lim, C.Y., Sadasivam, A., Lovatt, M., Wang, S.T., Ali, Y., Borchers, A., Sampath, K., Dunn, N.R. (2014) The PDZ domain protein Mcc is a novel effector of non-canonical Wnt signaling during convergence and extension in zebrafish. Development (Cambridge, England). 141:3505-16
Castanon, I., Abrami, L., Holtzer, L., Heisenberg, C.P., van der Goot, F.G., and González-Gaitán, M. (2013) Anthrax toxin receptor 2a controls mitotic spindle positioning. Nature cell biology. 15(1):28-39
Chen, Q., Takada, R., and Takada, S. (2012) Loss of Porcupine impairs convergent extension during gastrulation in zebrafish. Journal of Cell Science. 125(9):2224-2234
Lou, Q., He, J., Hu, L., and Yin, Z. (2012) Role of lbx2 in the noncanonical Wnt signaling pathway for convergence and extension movements and hypaxial myogenesis in zebrafish. Biochimica et biophysica acta. Molecular cell research. 1823(5):1024-1032

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