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Fig. 6 Schematic representation of UV-531-induced developmental neurotoxicity and MS-like symptoms. Exposure to UV-531 induces a significant upregulation of cacna1a, leading to increased Ca2+ inflow, resulting in an imbalance in calcium homeostasis as well as neuronal damage. It also caused microglia activation, inducing an inflammatory environment that drove myelin injure. Thus, UV-531 induced developmental neurotoxicity and MS-like symptoms.
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