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Figure 10
The proposed mechanism underlying the effect of 30% EF on activating 4E-BP1 under PD conditions. MPTP-induced intracellular alterations lead to a decrease in 4E-BP1 expression, enhancing eIF4F complex formation and potentially facilitating abnormal protein synthesis. In contrast, the application of 30% EF counteracts these effects by up-regulating 4E-BP1, which restores translational homeostasis and cellular damage, ultimately alleviating Parkinsonian symptoms.
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Full text @ Int. J. Mol. Sci.