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Figure Caption
Fig. 5 ATP5PO overexpression shows epistasis with RET. Quantification of the percentage of larvae presenting with ENS phenotypes reminiscent of HSCR in the different experimental groups. Due to ATP5PO overexpression in the retSA2684/+ background, more larvae significantly present with a phenotype reminiscent of total colonic HSCR (black bars), compared to retSA2684/+ alone. ***p < 0.001, **p < 0.01.
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Reprinted from Biochimica et biophysica acta. Molecular basis of disease, 1870(3), Kuil, L.E., Chauhan, R.K., de Graaf, B.M., Cheng, W.W., Kakiailatu, N.J.M., Lasabuda, R., Verhaeghe, C., Windster, J.D., Schriemer, D., Azmani, Z., Brooks, A.S., Edie, S., Reeves, R.H., Eggen, B.J.L., Shepherd, I.T., Burns, A.J., Hofstra, R.M.W., Melotte, V., Brosens, E., Alves, M.M., ATP5PO levels regulate enteric nervous system development in zebrafish, linking Hirschsprung disease to Down Syndrome, 166991, Copyright (2023) with permission from Elsevier. Full text @ BBA Molecular Basis of Disease