ZFIN Image: Dasgupta et al., 2021, FIGURE 3

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FIGURE 3

Major gene ontology (GO) processes across FRCs based on (A) differentially expressed mRNAs and (B) target mRNAs of differentially expressed miRs. GO was analyzed using human orthologs within Metacore. For panel (B), differentially expressed miRs were imported into TFmiR and both experimentally validated, and computationally predicted gene targets were imported into Metacore for GO analysis. Data is represented as -log (FDR p value) for each term; a value of ∼1.3 represents FDR p threshold of 0.05. Numbers within cells represent the significant -log (FDR p value). (C) Expression of representative mRNAs known to regulate nervous system development and neurotransmitter activity. Horizontal lines with numbers (1–7) represent FRC class based on Figure 1.

Acknowledgments

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