ZFIN Image: Amigo et al., 2018, Figure 5

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Figure 5

Unanswered questions in RPRM gene family. RPRM is as a p53-induced protein which induces cell cycle arrest at the G2/M checkpoint [4], through an unknown mechanism. Recently, RPRM genes have been shown to be expressed during brain, gut and blood vessel development [2]. Additional functions for RPRM include its role as a potential tumor suppressor gene (TSG), and a biomarker—through the assessment of the methylation status of its promoter region—for non-invasive detection of gastric cancer and other tumors [48,62]. Much like RPRM, RPRML is also expressed during embryonic development [2], but its role in physiological processes has never been investigated.

Acknowledgments

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