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Fig. 3
Ultrastructure of propylthiouracil-exposed zebrafish thyroids. At 50 mg/L, an electron-dense cytoplasm and shrunken nuclei present first symptoms of degeneration (A). Increased amounts of heterochromatin are visible (A, B). Marked proliferation, dilation, and fenestration in the rough endoplasmic reticulum (▸) are further alterations (A). The apical regions display proliferations of lysosomes (*; A). Magnifications: A: 10,000×; B: 4,000×.
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Full text @ Toxicol. Pathol.