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Fig. 6
Cyp26a1 has cell non-autonomous consequences on RA signaling levels within the local environment. (A–A3, C–C3) Tg(β-actin:GDBD-RLBD);(UAS:EGFP) donor cells transplanted into WT hosts injected with mrfp mRNA have EGFP expression in the notochord and spinal cord. (B–B3, D–D3) Tg(β-actin:GDBD-RLBD);(UAS:EGFP) donor cells transplanted vp-rar mRNA injected hosts with mrfp mRNA have severely dampened GFP expression. (E) Table showing summary of blastula transplantation results. Asterisks indicate statistically different from controls (p<0.05) using a modified chi-square test.
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Reprinted from Developmental Biology, 405(1), Rydeen, A., Voisin, N., D'Aniello, E., Ravisankar, P., Devignes, C.S., Waxman, J.S., Excessive feedback of Cyp26a1 promotes cell non-autonomous loss of retinoic acid signaling, 47-55, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.