ZFIN Image: Toruno et al., 2014, Fig. 5

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Figure Caption

Fig. 5

Bad radiosensitizes zebrafish neural tissue through the mitochondrial apoptosis pathway.

(A) Shown are lateral views of 27-hpf wild-type embryos (head is top left in each panel) injected with either 1) 50 pg of egfp mRNA, 2) 25 pg each of egfp and bad, 3) 25 pg each of egfp and zbcl-xL, or 4) 25 pg each of bad and zbcl-xL. At 24 hpf, half of each group was irradiated with 8 Gy IR and analyzed three hours later by the Casp3 assay. (B) Fluorescence intensity was measured in the spinal cords of at least 10 embryos from each group. Data represent one experiment, but the experiment was independently performed three times with similar results.

Acknowledgments

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