Image
|
Figure Caption
Fig. 6
Igf signaling is required for heart regeneration.
Wild type fish were treated DMSO (A) (n = 6) or the Igf1r inhibitor NVP-AEW541 (n = 7) (B and C) from 2–30 dpa. AFOG staining was performed at 30 dpa to detect collagen (blue) and fibrin (red) deposition. The dashed line marks the regenerating area. Scale bar = 100 μm. ia: injured area. (D) Quantification of scar area normalized to ventricle area in DMSO and NVP-AEW541 treated hearts. A significant increase (*p<0.05) in scar/ventricular area ratio was detected in NVP-AEW541 treated hearts.
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Full text @ PLoS One