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Fig. 8
Swap70 loss-of-function does not affect OPC morphology and differentiation. Images of migrating OPCs (A, B) and wrapping oligodendrocytes (C, D) in living 3 dpf larvae visualized using a Tg(nkx2.2a:mEGFP) transgenic reporter. Membrane processes of OPCs and myelinating oligodendrocytes appear normal in MOswap70-sp-injected larvae. (E, F) plp1a mRNA expression at 3 dpf. (G, H) mbp mRNA expression at 3 dpf. Both plp1a and mbp appear to be expressed at normal levels in MOswap70-sp-injected larvae, although the number of cells expressing these genes in MO-injected larvae is fewer than in wild type.
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Reprinted from Molecular and cellular neurosciences, 48(3), Takada, N., and Appel, B., swap70 Promotes neural precursor cell cycle exit and oligodendrocyte formation, 225-35, Copyright (2011) with permission from Elsevier. Full text @ Mol. Cell Neurosci.