IMAGE

Fig. 8

ID
ZDB-IMAGE-080401-42
Genes
Source
Figures for Ignatius et al., 2008
Image
Figure Caption

Fig. 8 Foxd3 negatively regulates mitfa. (A–D) Lateral views of mitfa in situ hybridizations of 32 hpf embryos. (B, D) There is an increase in the number of mitfa-positive melanoblasts in hdac1col/foxd3 mutant/morphant embryos as compared to uninjected hdac1col mutants. (A, C) In wild-type/foxd3 morphant embryos mitfa expression in melanoblasts is more robust than uninjected controls. (E–H) Lateral views of c-kit in situ hybridizations in 32 hpf embryos. (F, H) There is no rescue of c-kit expression in melanoblasts in hdac1col/foxd3 mutant morphants when compared to uninjected hdac1col mutants at 32 hpf. (E, G) Qualitatively, there are fewer c-kit positive melanoblasts in foxd3 morpholino treated wild-type embryos as compared to uninjected wild-type embryos. (E–H) In contrast to melanoblast expression, there is no difference in c-kit expression in the post anal region between wild-type, hdac1col mutants, wt/foxd3 wild-type/morphants and hdac1col/foxd3 mutant/morphant embryos (arrows).

Figure Data
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 313(2), Ignatius, M.S., Moose, H.E., El-Hodiri, H.M., and Henion, P.D., colgate/hdac1 repression of foxd3 expression is required to permit mitfa-dependent melanogenesis, 568-583, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.