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Fig. 1

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ZDB-IMAGE-080401-35
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Figures for Ignatius et al., 2008
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Fig. 1 Melanophore development is defective in hdac1col mutants. Lateral views of live embryos at 27 hpf (A, B) and 3 dpf (C, D). (A, B) At 27 hpf in wild-type embryos melanophores are present posterior to the eye and otic vesicle and are migrating over the flank of the embryo. In hdac1col mutants, there are fewer melanophores and most of the melanophores are located posterior to the otic vesicle (arrowhead). There are no migrating melanophores in hdac1col mutants. (C, D) By 3 dpf, melanophores are present in four stripes in wild-type: dorsal (d), lateral (l), ventral (v) and yolk (y). In hdac1col mutants melanophore numbers do not recover. Melanophores present in hdac1col fail to migrate and are mainly localized to the dorsal stripe and a patch of melanophores posterior to the otic vesicle (arrows, arrowhead). Melanophores that do migrate ventrally in hdac1col fail to migrate and are mainly localized to the dorsal stripe and a patch of melanophores posterior to the otp>col mutants are present in the anterior ventral stripe over the yolk extension. Xanthophores, which give a yellowish hue to embryos, are present in the head and over the flank of wild-type embryos and hdac1col mutants.

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Reprinted from Developmental Biology, 313(2), Ignatius, M.S., Moose, H.E., El-Hodiri, H.M., and Henion, P.D., colgate/hdac1 repression of foxd3 expression is required to permit mitfa-dependent melanogenesis, 568-583, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.