Gene

pparab

ID
ZDB-GENE-990415-211
Name
peroxisome proliferator-activated receptor alpha b
Symbol
pparab Nomenclature History
Previous Names
  • PPAR[a]
  • ppara1 (1)
  • ppara
  • pparal
  • nr1c1b (1)
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have several functions, including DNA-binding transcription factor activity; RNA polymerase II repressing transcription factor binding activity; and nuclear receptor transcription coactivator activity. Involved in cellular response to cold and response to activity. Predicted to localize to RNA polymerase II transcription factor complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Is expressed in several structures, including digestive system; female organism; immature eye; nervous system; and spinal cord neural tube. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
20 figures from 15 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pparab Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Hyperapobetalipoproteinemia, susceptibility to}
Associated With pparab Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Family IPR001723 Nuclear hormone receptor
Family IPR003074 Peroxisome proliferator-activated receptor
Family IPR003076 Peroxisome proliferator-activated receptor alpha
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
Domain Details Per Protein
Protein Length Nuclear hormone receptor Nuclear hormone receptor, ligand-binding domain Nuclear hormone receptor-like domain superfamily Peroxisome proliferator-activated receptor Peroxisome proliferator-activated receptor alpha Zinc finger, NHR/GATA-type Zinc finger, nuclear hormone receptor-type
UniProtKB:Q1L688 163
UniProtKB:O42546 44
UniProtKB:K7DY57 459
UniProtKB:A6XMH7 459
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations