Gene
rarab
- ID
- ZDB-GENE-980526-72
- Name
- retinoic acid receptor, alpha b
- Symbol
- rarab Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have several functions, including DNA-binding transcription factor activity; RNA polymerase II regulatory region sequence-specific DNA binding activity; and nuclear receptor transcription coactivator activity. Involved in animal organ development and pectoral fin development. Predicted to localize to RNA polymerase II transcription factor complex. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia; lung cancer (multiple); and syndromic microphthalmia. Is expressed in several structures, including endoderm; hindbrain neural keel; mesoderm; nervous system; and neural plate. Orthologous to several human genes including RARA (retinoic acid receptor alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 37 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu883 (15 images)
- eu941 (15 images)
- l03399 (37 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute promyelocytic leukemia | Alliance | Leukemia, acute promyelocytic | 612376 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Domain | IPR047158 | Retinoic acid receptor, ligand-binding domain |
| Domain | IPR047159 | Retinoic acid receptor, DNA-binding domain |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR003078 | Retinoic acid receptor |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Nuclear hormone receptor | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Retinoic acid receptor | Retinoic acid receptor, DNA-binding domain | Retinoic acid receptor, ligand-binding domain | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZTI3
|
458 | ||||||||
|
UniProtKB:E7EZ95
|
460 |
Interactions and Pathways
Plasmids
No data available