Gene

vdrb

ID
ZDB-GENE-080403-10
Name
vitamin D receptor b
Symbol
vdrb Nomenclature History
Previous Names
  • gb:dq017633
  • NR1I1-B (1)
  • nr1i1b (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Exhibits nuclear receptor activity. Contributes to DNA-binding transcription factor activity and vitamin D response element binding activity. Involved in embryonic heart tube morphogenesis and inner ear development. Predicted to localize to RNA polymerase II transcription factor complex. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hypersensitivity disease (multiple); carcinoma (multiple); liver disease (multiple); melanoma (multiple); and tuberculosis (multiple). Is expressed in several structures, including digestive system; heart; intestinal bulb primordium; nervous system; and pleuroperitoneal region. Orthologous to human VDR (vitamin D receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With vdrb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
vitamin D-dependent rickets type 2A Alliance Rickets, vitamin D-resistant, type IIA 277440
Associated With vdrb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Domain IPR042153 VDR, DNA-binding domain
Family IPR000324 Vitamin D receptor
Family IPR001723 Nuclear hormone receptor
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
Domain Details Per Protein
Protein Length Nuclear hormone receptor Nuclear hormone receptor, ligand-binding domain Nuclear hormone receptor-like domain superfamily VDR, DNA-binding domain Vitamin D receptor Zinc finger, NHR/GATA-type Zinc finger, nuclear hormone receptor-type
UniProtKB:I3IT83 92
UniProtKB:A0A2R8Q5G4 424
UniProtKB:Q1L673 422
UniProtKB:A0A088GEY4 422
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations