Gene

cntnap2b

ID
ZDB-GENE-070912-26
Name
contactin associated protein 2b
Symbol
cntnap2b Nomenclature History
Previous Names
  • cntnap2 (1)
  • si:ch211-120f16.4
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to act upstream of or within cell adhesion. Predicted to be located in membrane and paranodal junction. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in several diseases, including autism spectrum disorder (multiple); communication disorder (multiple); cortical dysplasia-focal epilepsy syndrome; major depressive disorder; and social phobia. Orthologous to human CNTNAP2 (contactin associated protein 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa39945Allele with one point mutationUnknownSplice SiteENU
ya1955Allele with one insertionExon 4Frameshift, Premature Stopzinc finger nuclease
ya2043Allele with one deletionExon 2Frameshift, Premature Stopzinc finger nuclease
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-cntnap2b
    (2)
    CRISPR2-cntnap2b
      (2)
      1 - 2 of 2
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      Human Disease
      Associated With cntnap2b Human Ortholog
      Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
      cortical dysplasia-focal epilepsy syndrome Alliance Pitt-Hopkins like syndrome 1 610042
      {Autism susceptibility 15} 612100
      1 - 2 of 2
      Associated With cntnap2b Via Experimental Models
      No data available
      Gene Ontology
      Protein Domains
      Domain, Family, and Site Summary
      Type InterPro ID Name
      Domain IPR000421 Coagulation factor 5/8, C-terminal domain
      Domain IPR000742 EGF-like domain
      Domain IPR001791 Laminin G domain
      Domain IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
      Domain IPR003585 Neurexin/syndecan/glycophorin C
      1 - 5 of 9 Show all
      Domain Details Per Protein
      Protein Additional Resources Length Coagulation factor 5/8, C-terminal domain Concanavalin A-like lectin/glucanase domain superfamily EGF-like domain Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain Fibrinogen-like, C-terminal Galactose-binding-like domain superfamily Laminin G domain Neurexin-related cell adhesion and synaptic protein Neurexin/syndecan/glycophorin C
      UniProtKB:L7NKK5 InterPro 1315
      1 - 1 of 1
      Transcripts
      Genome Browsers
      Genome Build: GRCz11Chromosome: 2
      Type Name Annotation Method Has Havana Data Length (nt) Analysis
      mRNA cntnap2b-201 (1) Ensembl 4,750 nt
      mRNA cntnap2b-202 (1) Ensembl 4,126 nt
      1 - 2 of 2
      Interactions and Pathways
      No data available
      Antibodies
      Name Type Antigen Genes Isotype Host Organism Assay Source Citations
      Ab1-cntnap2
      • WB
      1
      1 - 1 of 1
      Plasmids
      No data available
      Constructs
      No data available
      Marker Relationships
      Relationship Marker Type Marker Accession Numbers Citations
      Contained inBACCH211-120F16ZFIN Curated Data
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      Sequences
      Orthology
      Comparative Orthology
      Alliance
      Gene Tree
      Ensembl
      Species Symbol Chromosome Accession # Evidence
      HumanCNTNAP27
      Amino acid sequence comparison (1)
      Conserved genome location (synteny) (1)
      Citations
      1 - 10 of 11
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