PUBLICATION

Neuronal birth order identifies a dimorphic sensorineural map

Authors
Pujol-Martí, J., Zecca, A., Baudoin, J.P., Faucherre, A., Asakawa, K., Kawakami, K., and Lopez-Schier, H.
ID
ZDB-PUB-120306-5
Date
2012
Source
The Journal of neuroscience : the official journal of the Society for Neuroscience   32(9): 2976-2987 (Journal)
Registered Authors
Asakawa, Kazuhide, Faucherre, Adele, Kawakami, Koichi, Lopez-Schier, Hernan, Marti, Jesus Pujol, Zecca, Andrea
Keywords
none
MeSH Terms
  • Animals
  • Animals, Genetically Modified
  • Base Sequence
  • Lateral Line System/cytology
  • Lateral Line System/embryology*
  • Lateral Line System/physiology*
  • Mechanoreceptors/physiology
  • Molecular Sequence Data
  • Neurogenesis/physiology*
  • Neurons, Afferent/physiology
  • Sensory Receptor Cells/physiology*
  • Zebrafish
PubMed
22378871 Full text @ J. Neurosci.
Abstract

Spatially distributed sensory information is topographically mapped in the brain by point-to-point correspondence of connections between peripheral receptors and central target neurons. In fishes, for example, the axonal projections from the mechanosensory lateral line organize a somatotopic neural map. The lateral line provides hydrodynamic information for intricate behaviors such as navigation and prey detection. It also mediates fast startle reactions triggered by the Mauthner cell. However, it is not known how the lateralis neural map is built to subserve these contrasting behaviors. Here we reveal that birth order diversifies lateralis afferent neurons in the zebrafish. We demonstrate that early- and late-born lateralis afferents diverge along the main axes of the hindbrain to synapse with hundreds of second-order targets. However, early-born afferents projecting from primary neuromasts also assemble a separate map by converging on the lateral dendrite of the Mauthner cell, whereas projections from secondary neuromasts never make physical contact with the Mauthner cell. We also show that neuronal diversity and map topology occur normally in animals permanently deprived of mechanosensory activity. We conclude that neuronal birth order correlates with the assembly of neural submaps, whose combination is likely to govern appropriate behavioral reactions to the sensory context.

Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes