Gene
dagla
- ID
- ZDB-GENE-070619-1
- Name
- diacylglycerol lipase, alpha
- Symbol
- dagla Nomenclature History
- Previous Names
-
- nsddr (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables lipoprotein lipase activity. Acts upstream of or within several processes, including endocannabinoid signaling pathway; optokinetic behavior; and swimming behavior. Predicted to be located in membrane. Predicted to be active in cytoplasm; dendrite membrane; and postsynaptic membrane. Is expressed in brain and cranial ganglion. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human DAGLA (diacylglycerol lipase alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Martella et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-dagla | N/A | Martella et al., 2016 |
| MO2-dagla | N/A | Martella et al., 2016 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neuroocular syndrome 2, paroxysmal type | 168885 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha/Beta hydrolase fold | Diacylglycerol Lipase-Related | Fungal lipase-type domain |
|---|---|---|---|---|---|
| UniProtKB:A0A8N7T821 | InterPro | 1051 | |||
| UniProtKB:A0A8M3BAT1 | InterPro | 906 | |||
| UniProtKB:E7F0B3 | InterPro | 1051 | |||
| UniProtKB:A0AB32TZ29 | InterPro | 906 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-119P20 | ZFIN Curated Data | |
| Contained in | BAC | CH211-132L2 | ZFIN Curated Data | |
| Contained in | BAC | CH211-236C4 | ||
| Contained in | BAC | RP71-3A8 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009302951 (1) | 6748 nt | ||
| Genomic | GenBank:BX120015 | 156089 nt | ||
| Polypeptide | UniProtKB:A0A8N7T821 (1) | 1051 aa |
- Comparative Orthology
- Alliance
- Knuth, M.M., Stutts, W.L., Ritter, M.M., Garrard, K.P., Kullman, S.W. (2021) Vitamin D deficiency promotes accumulation of bioactive lipids and increased endocannabinoid tone in zebrafish. Journal of Lipid Research. 62:100142
- Orr, S.A., Ahn, S., Park, C., Miller, T.H., Kassai, M., Issa, F.A. (2021) Social Experience Regulates Endocannabinoids Modulation of Zebrafish Motor Behaviors. Frontiers in behavioral neuroscience. 15:668589
- Forner-Piquer, I., Beato, S., Piscitelli, F., Santangeli, S., Di Marzo, V., Habibi, H.R., Maradonna, F., Carnevali, O. (2020) Effects of BPA on zebrafish gonads: Focus on the endocannabinoid system. Environmental pollution (Barking, Essex : 1987). 264:114710
- Forner-Piquer, I., Santangeli, S., Maradonna, F., Rabbito, A., Piscitelli, F., Habibi, H.R., Di Marzo, V., Carnevali, O. (2018) Disruption of the gonadal endocannabinoid system in zebrafish exposed to diisononyl phthalate. Environmental pollution (Barking, Essex : 1987). 241:1-8
- Forner-Piquer, I., Santangeli, S., Maradonna, F., Verde, R., Piscitelli, F., di Marzo, V., Habibi, H.R., Carnevali, O. (2018) Role of Bisphenol A on the Endocannabinoid System at central and peripheral levels: Effects on adult female zebrafish. Chemosphere. 205:118-125
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Forner-Piquer, I., Maradonna, F., Gioacchini, G., Santangeli, S., Allarà, M., Piscitelli, F., Habibi, H.R., Di Marzo, V., Carnevali, O. (2017) Dose - specific effects of Di-isononyl phthalate on the endocannabinoid system and on liver of female zebrafish. Endocrinology. 158(10):3462-3476
- Martella, A., Sepe, R.M., Silvestri, C., Zang, J., Fasano, G., Carnevali, O., De Girolamo, P., Neuhauss, S.C., Sordino, P., Di Marzo, V. (2016) Important role of endocannabinoid signaling in the development of functional vision and locomotion in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 30(12):4275-4288
- Martella, A., Silvestri, C., Maradonna, F., Gioacchini, G., Allarà, M., Radaelli, G., Overby, D.R., Di Marzo, V., Carnevali, O. (2016) Bisphenol A induces fatty liver by an endocannabinoid-mediated positive feedback loop. Endocrinology. 157(5):1751-63
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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