ZFIN is now using GRCz12tu for Genomic Data
Gene
adpgk
- ID
- ZDB-GENE-061103-421
- Name
- ADP-dependent glucokinase
- Symbol
- adpgk Nomenclature History
- Previous Names
-
- DrADPGK1 (1)
- zgc:153956
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable ADP-specific glucokinase activity. Predicted to be involved in glucose metabolic process. Predicted to act upstream of or within phosphorylation. Predicted to be active in endoplasmic reticulum. Is expressed in brain; heart; liver; muscle; and notochord. Orthologous to human ADPGK (ADP dependent glucokinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Imle et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa24587 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-adpgk | N/A | Imle et al., 2019 |
| MO2-adpgk | N/A | Imle et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ADP-specific phosphofructokinase/glucokinase | Ribokinase-like |
|---|---|---|---|---|
| UniProtKB:A0A286YBG9 | InterPro | 497 | ||
| UniProtKB:A0JML7 | InterPro | 498 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-117K16 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:153956 | ZFIN Curated Data |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001079965 (1) | 2484 nt | ||
| Genomic | GenBank:BX957346 (2) | 149598 nt | ||
| Polypeptide | UniProtKB:A0JML7 (1) | 498 aa |
- Imle, R., Wang, B.T., Stützenberger, N., Birkenhagen, J., Tandon, A., Carl, M., Himmelreich, N., Thiel, C., Gröne, H.J., Poschet, G., Völkers, M., Gülow, K., Schröder, A., Carillo, S., Mittermayr, S., Bones, J., Kamiński, M.M., Kölker, S., Sauer, S.W. (2019) ADP-dependent glucokinase regulates energy metabolism via ER-localized glucose sensing. Scientific Reports. 9:14248
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- González-Alvarez, R., Ortega-Cuellar, D., Hernández-Mendoza, A., Moreno-Arriola, E., Villaseñor-Mendoza, K., Gálvez-Mariscal, A., Pérez-Cruz, M.E., Morales-Salas, I., and Velázquez-Arellano, A. (2009) The hexokinase gene family in the zebrafish: Structure, expression, functional and phylogenetic analysis. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 152(2):189-195
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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