Gene

crebbpa

ID

ZDB-GENE-050208-439

Name

CREB binding protein a

Symbol

crebbpa Nomenclature History

Previous Names

CBP-B (1)
crebbp
CREBBPb (1)
si:dkey-206l1.6
si:dkey-44g23.1

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have histone acetyltransferase activity; transcription coactivator activity; and zinc ion binding activity. Involved in hematopoietic progenitor cell differentiation. Localizes to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Is expressed in several structures, including blastoderm; blastodisc; digestive system; segmental plate; and solid lens vesicle. Orthologous to human CREBBP (CREB binding protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

dq017641 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Batut et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With crebbpa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Rubinstein-Taybi syndrome	Alliance	Rubinstein-Taybi syndrome 1	180849
		Menke-Hennekam syndrome 1	618332

Associated With crebbpa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018359	Bromodomain, conserved site
Domain	IPR000197	Zinc finger, TAZ-type
Domain	IPR000433	Zinc finger, ZZ-type
Domain	IPR001487	Bromodomain
Domain	IPR003101	Coactivator CBP, KIX domain
Domain	IPR010303	CREB-binding protein/p300, atypical RING domain
Domain	IPR014744	Nuclear receptor coactivator, CREB-bp-like, interlocking
Domain	IPR031162	CBP/p300-type histone acetyltransferase domain
Family	IPR013178	Histone acetyltransferase Rtt109/CBP
Homologous_superfamily	IPR009110	Nuclear receptor coactivator, interlocking
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR035898	TAZ domain superfamily
Homologous_superfamily	IPR036427	Bromodomain-like superfamily
Homologous_superfamily	IPR036529	Coactivator CBP, KIX domain superfamily
Homologous_superfamily	IPR037073	Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily
Homologous_superfamily	IPR038547	CBP/p300, atypical RING domain superfamily
Homologous_superfamily	IPR043145	Zinc finger, ZZ-type superfamily

Domain Details Per Protein

Protein	Length	Bromodomain	Bromodomain, conserved site	Bromodomain-like superfamily	CBP/p300, atypical RING domain superfamily	CBP/p300-type histone acetyltransferase domain	Coactivator CBP, KIX domain	Coactivator CBP, KIX domain superfamily	CREB-binding protein/p300, atypical RING domain	Histone acetyltransferase Rtt109/CBP	Nuclear receptor coactivator, CREB-bp-like, interlocking	Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily	Nuclear receptor coactivator, interlocking	TAZ domain superfamily	Zinc finger, RING/FYVE/PHD-type	Zinc finger, TAZ-type	Zinc finger, ZZ-type	Zinc finger, ZZ-type superfamily
UniProtKB:A0A8M9PDM0 InterPro	2346
UniProtKB:A0A8M9PQB0 InterPro	2264
UniProtKB:A0A0R4IPF2 InterPro	2349
UniProtKB:A0A2R8Q4T2 InterPro	2267
UniProtKB:A0A8M9Q3D9 InterPro	2347
UniProtKB:A0A8M2B8L6 InterPro	2350

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	crebbpa-201 (1) Ensembl	Havana	8544 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab3-crebbpa	polyclonal	crebbpa		Rabbit	IHC WB		1
Ab2-crebbpa	polyclonal	crebbpa		Rabbit	IHC WB		1
Ab1-crebbp	polyclonal	crebbpa	IgG	Rabbit	IHC	Santa Cruz Biotechnology, Inc.	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations