Gene

pparaa

ID
ZDB-GENE-041210-169
Name
peroxisome proliferator-activated receptor alpha a
Symbol
pparaa Nomenclature History
Previous Names
  • PPAR[a](III)
  • ppara2 (1)
  • ppara3
  • ppara
  • NR1C1-A (1)
  • nr1c1a (1)
  • PPARalpha-A (1)
  • si:ch211-239e6.3
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to have several functions, including DNA-binding transcription factor activity; RNA polymerase II repressing transcription factor binding activity; and nuclear receptor transcription coactivator activity. Predicted to be involved in several processes, including negative regulation of cholesterol storage; positive regulation of fatty acid metabolic process; and regulation of transcription by RNA polymerase II. Predicted to localize to RNA polymerase II transcription factor complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Is expressed in several structures, including digestive system; heart; immature eye; nervous system; and spinal cord neural tube. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
17 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pparaa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Hyperapobetalipoproteinemia, susceptibility to}
Associated With pparaa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Family IPR001723 Nuclear hormone receptor
Family IPR003074 Peroxisome proliferator-activated receptor
Family IPR003076 Peroxisome proliferator-activated receptor alpha
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
Domain Details Per Protein
Protein Length Nuclear hormone receptor Nuclear hormone receptor, ligand-binding domain Nuclear hormone receptor-like domain superfamily Peroxisome proliferator-activated receptor Peroxisome proliferator-activated receptor alpha Zinc finger, NHR/GATA-type Zinc finger, nuclear hormone receptor-type
UniProtKB:O42548 31
UniProtKB:Q5RGZ2 470
UniProtKB:Q1L694 473
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations