Gene
mydgf
- ID
- ZDB-GENE-040718-183
- Name
- myeloid-derived growth factor
- Symbol
- mydgf Nomenclature History
- Previous Names
-
- zgc:92871
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to be involved in positive regulation of angiogenesis and positive regulation of endothelial cell proliferation. Predicted to be active in extracellular space. Orthologous to human MYDGF (myeloid derived growth factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6909128 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Houseright et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| uwm49 | Allele with one deletion | Exon 5 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mydgf | (2) | |
| MO1-mydgf | N/A | Houseright et al., 2021 |
| MO2-mydgf | N/A | Houseright et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR018887 | Myeloid-derived growth factor |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Myeloid-derived growth factor |
|---|---|---|---|
| UniProtKB:Q6DGL1 | InterPro | 164 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-63J24 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-49M19 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6909128 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:92871 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173844 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002480 (1) | 1477 nt | ||
| Genomic | GenBank:BX649252 (1) | 205949 nt | ||
| Polypeptide | UniProtKB:Q6DGL1 (1) | 164 aa |
- Houseright, R.A., Miskolci, V., Mulvaney, O., Bortnov, V., Mosher, D.F., Rindy, J., Bennin, D.A., Huttenlocher, A. (2021) Myeloid-derived growth factor regulates neutrophil motility in interstitial tissue damage. The Journal of cell biology. 220(8):
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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