Gene
map1lc3c
- ID
- ZDB-GENE-040426-1080
- Name
- microtubule-associated protein 1 light chain 3 gamma
- Symbol
- map1lc3c Nomenclature History
- Previous Names
-
- zgc:56565
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable phosphatidylethanolamine binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in cellular response to nitrogen starvation and macroautophagy. Predicted to be located in autophagosome; endomembrane system; and membrane. Predicted to be active in autophagosome membrane. Orthologous to human MAP1LC3C (microtubule associated protein 1 light chain 3 gamma).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Autophagy protein Atg8 ubiquitin-like | Microtubule-associated protein 1A/1B light chain 3C | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|
| UniProtKB:Q7ZWC0 | InterPro | 128 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
map1lc3c-201
(1)
|
Ensembl | 1,068 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(fli1:mCherry-GFP-map1lc3c) |
| 1 | Ai et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-155A10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56565 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200298 (1) | 808 nt | ||
| Genomic | GenBank:FO744859 (1) | 103420 nt | ||
| Polypeptide | UniProtKB:Q7ZWC0 (1) | 128 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | MAP1LC3C | 1 | Amino acid sequence comparison (1) |
- Godoi, F.G.A., Forner-Piquer, I., Randazzo, B., Habibi, H.R., Lo Nostro, F.L., Moreira, R.G., Carnevali, O. (2021) Effects of Di-Isononyl Phthalate (DiNP) on Follicular Atresia in Zebrafish Ovary. Frontiers in endocrinology. 12:677853
- Ai, X., Ye, Z., Yao, Y., Xiao, J., You, C., Xu, J., Huang, X., Zhong, J., Fan, M., Song, X., Shi, H., Zhang, D., Zhao, C. (2020) Endothelial Autophagy: an Effective Target for Radiation-induced Cerebral Capillary Damage. Scientific Reports. 10:614
- Hou, J., Liu, H., Zhang, S., Liu, X., Hayat, T., Alsaedi, A., Wang, X. (2019) Mechanism of toxic effects of Nano-ZnO on cell cycle of zebrafish (Danio rerio). Chemosphere. 229:206-213
- Ganesan, S., Moussavi Nik, S.H., Newman, M., Lardelli, M. (2014) Identification and expression analysis of the zebrafish orthologues of mammalian MAP1LC3 gene family. Experimental cell research. 328(1):228-37
- Benato, F., Skobo, T., Gioacchini, G., Moro, I., Ciccosanti, F., Piacentini, M., Fimia, G.M., Carnevali, O., and Dalla Valle, L. (2013) Ambra1 knockdown in zebrafish leads to incomplete development due to severe defects in organogenesis. Autophagy. 9(4):476-495
- Gioacchini, G., Valle, L.D., Benato, F., Fimia, G.M., Nardacci, R., Ciccosanti, F., Piacentini, M., Borini, A., and Carnevali, O. (2013) Interplay between autophagy and apoptosis in the development of Danio rerio follicles and the effects of a probiotic. Reproduction, fertility, and development. 25(8):1115-1125
- Yabu, T., Imamura, S., Mizusawa, N., Touhata, K., and Yamashita, M. (2012) Induction of Autophagy by Amino Acid Starvation in Fish Cells. Marine biotechnology (New York, N.Y.). 14(4):491-501
- Li, Y., Chia, J.M., Bartfai, R., Christoffels, A., Ding, K., Yue, G.H., Ho,M.Y., Hill, J.A., Stupka, E. and Orban, L (2004) Comparative analysis of the testis and ovary transcriptomes in zebrafish by combining experimental and computational tools. Comparative and functional genomics. 5(5):403-418
- Song, H.D., Sun, X.J., Deng, M., Zhang, G.W., Zhou, Y., Wu, X.Y., Sheng, Y., Chen, Y., Ruan, Z., Jiang, C.L., Fan, H.Y., Zon, L.I., Kanki, J.P., Liu, T.X., Look, A.T., and Chen, Z. (2004) Hematopoietic gene expression profile in zebrafish kidney marrow. Proceedings of the National Academy of Sciences of the United States of America. 101(46):16240-16245
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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