ZFIN is now using GRCz12tu for Genomic Data
Gene
fli1
- ID
- ZDB-GENE-980526-426
- Name
- Fli-1 proto-oncogene, ETS transcription factor
- Symbol
- fli1 Nomenclature History
- Previous Names
-
- fli-1
- fli1
- fli1a
- fli
- cb855 (1)
- wu:fc45b11
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within angiogenesis and positive regulation of DNA-binding transcription factor activity. Predicted to be active in nucleus. Is expressed in several structures, including angioblastic mesenchymal cell; cardiovascular system; hematopoietic system; mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in blood platelet disease and thrombocytopenia. Orthologous to human FLI1 (Fli-1 proto-oncogene, ETS transcription factor).
- Genome Resources
- Note
-
This gene is orthologous to Fli-1 proto-oncogene, ETS transcription factor, but analyses indicate that the ancestral gene was duplicated prior to the divergence of ray- and lobe-fin fishes and not the result of the WGD event in the ray-fin fishes, so the gene name has been updated to fli1.
- Comparative Information
-
- All Expression Data
- 211 figures from 145 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb855 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Liu et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Bleeding disorder, platelet-type, 21 | 617443 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000418 | Ets domain |
| Domain | IPR003118 | Pointed domain |
| Domain | IPR035573 | Friend leukemia integration 1 transcription factor, pointed domain |
| Family | IPR046328 | ETS family |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Ets domain | ETS family | Friend leukemia integration 1 transcription factor, pointed domain | Pointed domain | Sterile alpha motif/pointed domain superfamily | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9P9W7 | InterPro | 465 | |||||||
| UniProtKB:A0A2R8QGN6 | InterPro | 460 | |||||||
| UniProtKB:A0A8M9PF94 | InterPro | 456 | |||||||
| UniProtKB:A0A8M9PLW9 | InterPro | 474 | |||||||
| UniProtKB:Q9PU61 | InterPro | 451 | |||||||
| UniProtKB:A0A8M9P0Y3 | InterPro | 469 | |||||||
| UniProtKB:A0A8M9PPZ8 | InterPro | 423 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
- Genome Browsers