Gene

fli1

ID
ZDB-GENE-980526-426
Name
Fli-1 proto-oncogene, ETS transcription factor
Symbol
fli1 Nomenclature History
Previous Names
  • fli-1
  • fli1
  • fli1a
  • fli
  • cb855 (1)
  • wu:fc45b11
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in angiogenesis and positive regulation of DNA-binding transcription factor activity. Predicted to localize to nucleus. Is expressed in several structures, including angioblastic mesenchymal cell; cardiovascular system; hematopoietic system; mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in blood platelet disease and thrombocytopenia. Orthologous to human FLI1 (Fli-1 proto-oncogene, ETS transcription factor).
Genome Resources
Note
This gene is orthologous to Fli-1 proto-oncogene, ETS transcription factor, but analyses indicate that the ancestral gene was duplicated prior to the divergence of ray- and lobe-fin fishes and not the result of the WGD event in the ray-fin fishes, so the gene name has been updated to fli1.
Comparative Information
Expression
All Expression Data
206 figures from 140 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Liu et al., 2008
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fli1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Bleeding disorder, platelet-type, 21 617443
Associated With fli1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000418 Ets domain
Domain IPR003118 Pointed domain
Domain IPR035573 Friend leukemia integration 1 transcription factor, pointed domain
Family IPR046328 ETS family
Homologous_superfamily IPR013761 Sterile alpha motif/pointed domain superfamily
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Ets domain ETS family Friend leukemia integration 1 transcription factor, pointed domain Pointed domain Sterile alpha motif/pointed domain superfamily Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:A0A8M9P9W7 465
UniProtKB:A0A2R8QGN6 460
UniProtKB:A0A8M9PF94 456
UniProtKB:A0A8M9PLW9 474
UniProtKB:Q9PU61 451
UniProtKB:A0A8M9P0Y3 469
UniProtKB:A0A8M9PPZ8 423
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA fli1a-201 (1) Ensembl 2,973 nt
mRNA fli1a-202 (1) Ensembl 638 nt
mRNA fli1a-203 (1) Ensembl 577 nt
mRNA fli1a-204 (1) Ensembl 601 nt
mRNA fli1a-205 (1) Ensembl 1,470 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations