Gene

cacna1da

ID
ZDB-GENE-030616-135
Name
calcium channel, voltage-dependent, L type, alpha 1D subunit, a
Symbol
cacna1da Nomenclature History
Previous Names
  • cacna1d (1)
  • cav1.3a (1)
  • gem
  • gemini
  • si:dz136d19.3
  • si:dz223c6.1
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have high voltage-gated calcium channel activity. Involved in detection of mechanical stimulus involved in sensory perception of sound; neuromuscular process controlling balance; and synapse organization. Localizes to basal plasma membrane and ribbon synapse. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is expressed in central nervous system; heart; and neuromast. Orthologous to human CACNA1D (calcium voltage-gated channel subunit alpha1 D).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cacna1da Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Primary aldosteronism, seizures, and neurologic abnormalities 615474
Sinoatrial node dysfunction and deafness 614896
Associated With cacna1da Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR005821 Ion transport domain
Domain IPR014873 Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
Domain IPR031649 Voltage-dependent L-type calcium channel, IQ-associated domain
Domain IPR031688 Voltage-gated calcium channel subunit alpha, C-terminal
Family IPR002077 Voltage-dependent calcium channel, alpha-1 subunit
Family IPR005446 Voltage-dependent calcium channel, L-type, alpha-1 subunit
Homologous_superfamily IPR027359 Voltage-dependent channel domain superfamily
Domain Details Per Protein
Protein Length Ion transport domain Voltage-dependent calcium channel, alpha-1 subunit Voltage-dependent calcium channel, alpha-1 subunit, IQ domain Voltage-dependent calcium channel, L-type, alpha-1 subunit Voltage-dependent channel domain superfamily Voltage-dependent L-type calcium channel, IQ-associated domain Voltage-gated calcium channel subunit alpha, C-terminal
UniProtKB:B3DK08 2068
UniProtKB:A0A0R4IK24 2068
UniProtKB:A0A0R4IQX8 2082
UniProtKB:Q8JFR2 809
UniProtKB:Q7ZZ58 1374
UniProtKB:Q6QRQ2 2082
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-cacna1da polyclonal Rabbit
  • IHC
9
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations