Gene
fbxo5
- ID
- ZDB-GENE-030131-4027
- Name
- F-box protein 5
- Symbol
- fbxo5 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin ligase inhibitor activity. Acts upstream of or within several processes, including hemopoiesis; mitotic cytokinesis; and negative regulation of mitotic nuclear division. Predicted to be located in cytoplasm and spindle. Predicted to be active in nucleus. Is expressed in several structures, including alar plate midbrain region; blood; nervous system; optic vesicle; and segmental plate. Orthologous to human FBXO5 (F-box protein 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7158631 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- 24 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi2648Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| la012426Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la018683Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa8720 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18636 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31965 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa38972 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42299 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| ti245 | unknown | Unknown | Unknown | ENU | |
| tiy121 | Allele with one point mutation | Unknown | Unknown | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-fbxo5 | N/A | (2) |
| MO2-fbxo5 | N/A | Rhodes et al., 2009 |
| MO3-fbxo5 | N/A | Rhodes et al., 2009 |
| MO4-fbxo5 | N/A | Robu et al., 2012 |
| MO5-fbxo5 | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | F-box domain | F-box-like domain superfamily | F-box only protein 5/43 | IBR domain | Zinc finger ZBR-type domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q0V967 | InterPro | 384 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-fbxo5 | polyclonal | Rabbit |
|
Life Technologies (Invitrogen)
|
2 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-211G16 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-9B4 | ZFIN Curated Data | |
| Contains | SNP | rs3728595 | ZFIN Curated Data | |
| Contains | SNP | rs3728596 | ZFIN Curated Data | |
| Contains | SNP | rs3728597 | ZFIN Curated Data | |
| Contains | SNP | rs3728598 | ZFIN Curated Data | |
| Encodes | EST | fc65h02 | ||
| Encodes | EST | fe06e07 | ZFIN Curated Data | |
| Encodes | EST | fz79f03 | ||
| Encodes | EST | IMAGE:7158631 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003869 (1) | 1681 nt | ||
| Genomic | GenBank:CR847786 | 156551 nt | ||
| Polypeptide | UniProtKB:Q0V967 (1) | 384 aa |
- Cerveny, K.L., Bronstein, H., Hagen, O., Lamb, D.B., Martin, G., Tower, I., Van Duzer, A., Welch, E., Varga, M. (2021) Mutations linked to loss of cell cycle control can render cells responsive to local differentiation cues. microPublication. Biology. 2021:
- Fan, X., Hou, T., Guan, Y., Li, X., Zhang, S., Wang, Z. (2020) Genomic responses of DNA methylation and transcript profiles in zebrafish cells upon nutrient deprivation stress. The Science of the total environment. 722:137980
- Qiao, R., Deng, Y., Zhang, S., Wolosker, M.B., Zhu, Q., Ren, H., Zhang, Y. (2019) Accumulation of different shapes of microplastics initiates intestinal injury and gut microbiota dysbiosis in the gut of zebrafish. Chemosphere. 236:124334
- Anton, K.A., Kajita, M., Narumi, R., Fujita, Y., Tada, M. (2018) Src-transformed cells hijack mitosis to extrude from the epithelium. Nature communications. 9:4695
- Anderson, N.M., Li, D., Peng, H.L., Laroche, F.J., Mansour, M.R., Gjini, E., Aioub, M., Helman, D.J., Roderick, J.E., Cheng, T., Harrold, I., Samaha, Y., Meng, L., Amsterdam, A., Neuberg, D.S., Denton, T.T., Sanda, T., Kelliher, M.A., Singh, A., Look, A.T., Feng, H. (2016) The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis. Leukemia. 30(6):1365-74
- Warga, R.M., Wicklund, A., Richards, S.E., Kane, D.A. (2016) Progressive loss of RacGAP1/ogre activity has sequential effects on cytokinesis and zebrafish development. Developmental Biology. 418(2):307-22
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Buckley, C.E., Ren, X., Ward, L.C., Girdler, G.C., Araya, C., Green, M.J., Clark, B.S., Link, B.A., and Clarke, J.D. (2013) Mirror-symmetric microtubule assembly and cell interactions drive lumen formation in the zebrafish neural rod. The EMBO journal. 32(1):30-44
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Robu, M.E., Zhang, Y., and Rhodes, J. (2012) Rereplication in emi1-Deficient Zebrafish Embryos Occurs through a Cdh1-Mediated Pathway. PLoS One. 7(10):e47658
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