Gene

exosc8

ID
ZDB-GENE-030131-1736
Name
exosome component 8
Symbol
exosc8 Nomenclature History
Previous Names
  • Opa-interacting protein 2 (3' exoribonuclease family) (1)
  • wu:fb79a10
  • zgc:110381
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have AU-rich element binding activity. Involved in axonogenesis; cerebellar Purkinje cell layer structural organization; and myelination. Predicted to localize to cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia. Is expressed in alar plate midbrain region; immature eye; midbrain; and retina. Orthologous to human EXOSC8 (exosome component 8).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
16 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With exosc8 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
pontocerebellar hypoplasia type 1C Alliance Pontocerebellar hypoplasia, type 1C 616081
Associated With exosc8 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001247 Exoribonuclease, phosphorolytic domain 1
Domain IPR015847 Exoribonuclease, phosphorolytic domain 2
Family IPR033196 Exosome complex component Rrp43
Homologous_superfamily IPR020568 Ribosomal protein S5 domain 2-type fold
Homologous_superfamily IPR027408 PNPase/RNase PH domain superfamily
Homologous_superfamily IPR036345 Exoribonuclease, PH domain 2 superfamily
Domain Details Per Protein
Protein Length Exoribonuclease, PH domain 2 superfamily Exoribonuclease, phosphorolytic domain 1 Exoribonuclease, phosphorolytic domain 2 Exosome complex component Rrp43 PNPase/RNase PH domain superfamily Ribosomal protein S5 domain 2-type fold
UniProtKB:Q6DRN4 277
UniProtKB:A7MCN4 277
UniProtKB:Q4VBT6 277
UniProtKB:B2GSJ4 277
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations