Gene

esr2b

ID
ZDB-GENE-030116-1
Name
estrogen receptor 2b
Symbol
esr2b Nomenclature History
Previous Names
  • ER[b]1 (1)
  • ERbeta-A (1)
  • NR3A2-A (1)
  • zfER[b]1 (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Exhibits estrogen receptor activity; nuclear receptor activity; and steroid hormone binding activity. Involved in response to estrogen. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); autoimmune hypersensitivity disease (multiple); hypospadias; and neurodegenerative disease (multiple). Is expressed in several structures, including forebrain; head; liver; male organism; and pleuroperitoneal region. Orthologous to human ESR2 (estrogen receptor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
28 figures from 20 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With esr2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
ovarian dysgenesis 8 Alliance ?Ovarian dysgenesis 8 618187
Associated With esr2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Domain IPR021064 Estrogen receptor beta, N-terminal
Family IPR001723 Nuclear hormone receptor
Family IPR024178 Oestrogen receptor/oestrogen-related receptor
Family IPR028355 Estrogen receptor beta/gamma
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
Domain Details Per Protein
Protein Length Estrogen receptor beta/gamma Estrogen receptor beta, N-terminal Nuclear hormone receptor Nuclear hormone receptor, ligand-binding domain Nuclear hormone receptor-like domain superfamily Oestrogen receptor/oestrogen-related receptor Zinc finger, NHR/GATA-type Zinc finger, nuclear hormone receptor-type
UniProtKB:B8JJL4 600
UniProtKB:Q90Z59 200
UniProtKB:B8JJL3 592
UniProtKB:U3PYP4 72
UniProtKB:Q5PR29 592
UniProtKB:Q98SM8 592
UniProtKB:Q90WS9 592
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations