Gene
ruvbl2
- ID
- ZDB-GENE-030109-1
- Name
- RuvB-like AAA ATPase 2
- Symbol
- ruvbl2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables ATP hydrolysis activity. Involved in box C/D snoRNP assembly; chromatin organization; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cilium assembly; epithelial cilium movement involved in extracellular fluid movement; and regulation of heart growth. Predicted to be located in dynein axonemal particle and nucleus. Predicted to be part of R2TP complex and nuclear lumen. Is expressed in central nervous system; neural tube; posterior lateral line; and pronephric duct. Orthologous to human RUVBL2 (RuvB like AAA ATPase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63723 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | AAA+ ATPase domain | P-loop containing nucleoside triphosphate hydrolase | RuvB-like | RuvB-like, AAA-lid domain | RuvB-like helicase 2 | TIP49, P-loop domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:P83571
|
463 | ||||||
|
UniProtKB:A0A2R8QIK4
|
454 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
ruvbl2-201
(1)
|
1712 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-ruvbl2 | polyclonal | IgG | Rabbit |
|
Abcam plc
|
3 |
Plasmids
No data available