Gene

ruvbl2

ID
ZDB-GENE-030109-1
Name
RuvB-like AAA ATPase 2
Symbol
ruvbl2 Nomenclature History
Previous Names
  • liebeskummer (1)
  • lik (1)
  • reptin
  • wu:fi25f01
  • zreptin
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Enables ATP hydrolysis activity. Involved in box C/D snoRNP assembly; chromatin organization; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cilium assembly; epithelial cilium movement involved in extracellular fluid movement; and regulation of heart growth. Predicted to be located in dynein axonemal particle and nucleus. Predicted to be part of R2TP complex and nuclear lumen. Is expressed in central nervous system; neural tube; posterior lateral line; and pronephric duct. Orthologous to human RUVBL2 (RuvB like AAA ATPase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ruvbl2 Human Ortholog
No data available
Associated With ruvbl2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003593 AAA+ ATPase domain
Domain IPR010339 TIP49, P-loop domain
Domain IPR041048 RuvB-like, AAA-lid domain
Family IPR027238 RuvB-like
Family IPR037942 RuvB-like helicase 2
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length AAA+ ATPase domain P-loop containing nucleoside triphosphate hydrolase RuvB-like RuvB-like, AAA-lid domain RuvB-like helicase 2 TIP49, P-loop domain
UniProtKB:P83571 463
UniProtKB:A0A2R8QIK4 454
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-ruvbl2 polyclonal IgG Rabbit
  • IHC
  • WB
Abcam plc
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations