Gene
gnat1
- ID
- ZDB-GENE-011128-11
- Name
- guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
- Symbol
- gnat1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway; detection of light stimulus involved in visual perception; and phototransduction, visible light. Predicted to act upstream of or within visual perception. Predicted to be located in membrane. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in head; pineal complex; and visual system. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1G; congenital stationary night blindness autosomal dominant 3; and night blindness. Orthologous to human GNAT1 (G protein subunit alpha transducin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 45 figures from 27 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73094 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la025584Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-gnat1 | N/A | Nakao et al., 2012 |
| MO2-gnat1 | N/A | Nakao et al., 2012 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital stationary night blindness 1G | Alliance | Night blindness, congenital stationary, type 1G | 616389 |
| congenital stationary night blindness autosomal dominant 3 | Alliance | Night blindness, congenital stationary, autosomal dominant 3 | 610444 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR001019 | Guanine nucleotide binding protein (G-protein), alpha subunit |
| Family | IPR001408 | G-protein alpha subunit, group I |
| Homologous_superfamily | IPR011025 | G protein alpha subunit, helical insertion |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | G-protein alpha subunit, group I | G protein alpha subunit, helical insertion | Guanine nucleotide binding protein (G-protein), alpha subunit | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|
| UniProtKB:Q90WX6 | InterPro | 350 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-20F24 | ZFIN Curated Data | |
| Encodes | EST | fk56e06 | ||
| Encodes | cDNA | MGC:73094 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131868 (1) | 1900 nt | ||
| Genomic | GenBank:CU468905 (1) | 271044 nt | ||
| Polypeptide | UniProtKB:Q90WX6 (1) | 350 aa |
- Cao, M., Xu, T., Song, Y., Wei, S., Wang, H., Guo, X., Yin, D. (2024) Brominated Flame Retardant HBCD and Artificial Light at Night Synergically Caused Visual Disorder and Sleep Difficulty in Zebrafish Larvae. Environmental science & technology. 58(39):17247-17258
- Lo, C.H., Liu, Z., Chen, S., Lin, F., Berneshawi, A.R., Yu, C.Q., Koo, E.B., Kowal, T.J., Ning, K., Hu, Y., Wang, W.J., Liao, Y.J., Sun, Y. (2024) Primary cilia formation requires the Leigh syndrome-associated mitochondrial protein NDUFAF2. The Journal of Clinical Investigation. 134(13):
- McCann, T., Sundaramurthi, H., Walsh, C., Virdi, S., Alvarez, Y., Sapetto-Rebow, B., Collery, R.F., Carter, S.P., Moran, A., Mulholland, R., O'Connor, J.J., Taylor, M.R., Rauch, N., Starostik, M.R., English, M.A., Swaroop, A., Geisler, R., Reynolds, A.L., Kennedy, B.N. (2024) Emc1 is essential for vision and zebrafish photoreceptor outer segment morphogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 38:e70086e70086
- Volkov, L.I., Ogawa, Y., Somjee, R., Vedder, H.E., Powell, H.E., Poria, D., Meiselman, S., Kefalov, V.J., Corbo, J.C. (2024) Samd7 represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity. Proceedings of the National Academy of Sciences of the United States of America. 121:e2402121121e2402121121
- Liu, X., Han, S., Liu, F., Yu, S., Qin, Y., Li, J., Jia, D., Gao, P., Chen, X., Tang, Z., Liu, M., Huang, Y. (2023) Retinal degeneration in rpgra mutant zebrafish. Frontiers in cell and developmental biology. 11:11699411169941
- Lu, K., Liang, X.F., Tang, S.L., Wu, J., Zhang, L., Wang, Y., Chai, F. (2023) Role of short-wave-sensitive 1 (sws1) in cone development and first feeding in larval zebrafish. Fish physiology and biochemistry. 49(5):801-813
- Gao, P., Jia, D., Li, P., Huang, Y., Hu, H., Sun, K., Lv, Y., Chen, X., Han, Y., Zhang, Z., Ren, X., Wang, Q., Liu, F., Tang, Z., Liu, M. (2022) Accumulation of Lipid Droplets in a Novel Bietti Crystalline Dystrophy Zebrafish Model With Impaired PPARα Pathway. Investigative ophthalmology & visual science. 63:32
- Jia, D., Gao, P., Lv, Y., Huang, Y., Reilly, J., Sun, K., Han, Y., Hu, H., Chen, X., Zhang, Z., Li, P., Luo, J., Shu, X., Tang, Z., Liu, F., Liu, M., Ren, X. (2022) Tulp1 deficiency causes early-onset retinal degeneration through affecting ciliogenesis and activating ferroptosis in zebrafish. Cell Death & Disease. 13:962
- Cleghorn, W.M., Burrell, A.L., Giarmarco, M.M., Brock, D.C., Wang, Y., Chambers, Z.S., Du, J., Kollman, J.M., Brockerhoff, S.E. (2021) A highly conserved zebrafish IMPDH retinal isoform produces the majority of guanine and forms dynamic protein filaments in photoreceptor cells. The Journal of biological chemistry. 298(1):101441
- Ogawa, Y., Shiraki, T., Fukada, Y., Kojima, D. (2021) Foxq2 determines blue cone identity in zebrafish. Science advances. 7:eabi9784
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