Gene

csf1ra

ID
ZDB-GENE-001205-1
Name
colony stimulating factor 1 receptor, a
Symbol
csf1ra Nomenclature History
Previous Names
  • c-fms (1)
  • csf1r
  • fms (1)
  • pfe (1)
  • sal (1)
  • salz (1)
  • panther
  • pfeffer (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Is predicted to enable macrophage colony-stimulating factor receptor activity. Involved in hemopoiesis; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Acts upstream of or within several processes, including immune response in brain or nervous system; macrophage chemotaxis; and myeloid leukocyte differentiation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of CSF1-CSF1R complex and receptor complex. Is expressed in several structures, including hematopoietic cell; neural crest cell; osteoclast; pigment cell; and rostral blood island. Used to study CSF1R-related brain malformation and osteopetrosis. Human ortholog(s) of this gene implicated in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia and renal cell carcinoma. Orthologous to human CSF1R (colony stimulating factor 1 receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
72 figures from 50 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
53 figures from 23 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With csf1ra Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
adult-onset leukoencephalopathy with axonal spheroids and pigmented glia Alliance Leukoencephalopathy, diffuse hereditary, with spheroids 1 221820
Brain abnormalities, neurodegeneration, and dysosteosclerosis 618476
Associated With csf1ra Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Family IPR030658 Macrophage colony-stimulating factor 1 receptor
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Macrophage colony-stimulating factor 1 receptor Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, receptor class III, conserved site
UniProtKB:A0A0R4IML5 883
UniProtKB:A4JYH8 696
UniProtKB:Q9I8N6 977
UniProtKB:B3DHL0 977
UniProtKB:A0A2R8Q9U7 977
UniProtKB:A0A2R8QNM5 696
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-csf1ra polyclonal IgG Rabbit
  • WB
AnaSpec
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations