Gene

dazl

ID

ZDB-GENE-000405-6

Name

deleted in azoospermia-like

Symbol

dazl Nomenclature History

Previous Names

zDAZL

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Exhibits mRNA 3'-UTR binding activity; sequence-specific DNA binding activity; and translation activator activity. Involved in 3'-UTR-mediated mRNA stabilization and negative regulation of gene silencing by miRNA. Localizes to cytoplasm. Is expressed in blastodisc; gonad; unfertilized egg; and yolk. Orthologous to several human genes including DAZL (deleted in azoospermia like).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

40 figures from 31 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Bertho et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dazl Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Spermatogenic failure, susceptibility to}

Associated With dazl Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000504	RNA recognition motif domain
Domain	IPR037551	DAZ, RNA recognition motif, vertebrates
Domain	IPR043628	DAZ domain
Homologous_superfamily	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily	IPR035979	RNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	DAZ domain	DAZ, RNA recognition motif, vertebrates	Nucleotide-binding alpha-beta plait domain superfamily	RNA-binding domain superfamily	RNA recognition motif domain
UniProtKB:Q9YGW7 InterPro	229
UniProtKB:Q1LUN6 InterPro	229
UniProtKB:A0A8M2BHE4 InterPro	212

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dazl-201 (1) Ensembl	Havana	2035 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	dazl-202 (1) Ensembl	Havana	509 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	dazl-203 (1) Ensembl	Havana	2159 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	dazl-204 (1) Ensembl	Havana	831 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	dazl-205 (1) Ensembl	Havana	885 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	dazl-206 (1) Ensembl	Havana	919 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-dazl	polyclonal	dazl		Chicken	IHC		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations