FIGURE

Figure 4.

ID

ZDB-FIG-260902-4

Publication

Gan et al., 2026 - COMMD9-regulated endothelial cell abnormality-induced hypercoagulability is associated with Budd-Chiari syndrome

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Figure 4.

Knockdown of commd9 induces SIV malformation and elevates adhesion properties in zebrafish. (A) Alkaline phosphatase staining of larvae showing a reduction in the SIVs (white arrow) after commd9 inhibition using morpholino-modified oligonucleotide (MO). Scale bar, 100 μm. (B) Fluorescence imaging confirms similar SIV defects. Scale bar, 100 μm. Basket length in different treatment groups (right panel). (C) Proportions of treated larvae manifesting SIV anomalies. (D) Assessment of SIV anomalies in zebrafish injected with the commd9 MO alone or co-injected with wild-type commd9 mRNA (100 pg). Scale bar, 100 μm. (E) Number of adherent cells on fibronectin-coated substratum compared with that on the embryos injected with commd9 MO alone or co-injected with wild-type commd9 mRNA (100 pg). All micrographs show lateral views, with anterior to the left and dorsal above, N = 22–66 larvae per group. The results are shown as mean ± SD, ****P < 0.0001; n.s., not significant.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-commd9 y1Tg + MO1-commd9 (AB)
Knockdown Reagent:	MO1-commd9
Observed In:	subintestinal vein subintestinal vein sprouting angiogenesis
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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