FIGURE

FIGURE 2

ID

ZDB-FIG-260720-9

Publication

Perone et al., 2026 - Aip mutation leads to significant alterations in gene expression, altered sensitivity to Ahr ligands, and early lethality in zebrafish

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FIGURE 2

Behavioral analysis of DMSO-exposed five dpf larvae from the aip^wh239 line. Data is from control larvae for each of the four EC₅₀ Ahr ligand exposures. A linear mixed model was fit, including “dataset” as a variable to account for experiment-to-experiment variation. Genotype is presented on the x-axis, and larval movement in mm is presented on the y-axis for LPR and LSR total distance. Boxplots show the median (horizontal line), mean (circle), interquartile range (box), and 1.5x the interquartile range (whiskers). Significant differences between each genotype are denoted by an asterisk, * (p-value ≤0.05, type III ANOVA followed by pairwise t-tests of model-based estimated marginal means adjusted using Benjamini–Hochberg FDR correction). Unexposed aip^wh239−/− larvae had significantly increased movement in the LPR and LSR assays when compared to aip^wh239+/+ larvae.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	aip^wh239/wh239
Conditions:	acoustic radiation lighting conditions
Observed In:	response to light stimulus startle response
Stage:	Day 5

Phenotype Detail

Acknowledgments

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