FIGURE

Figure 2

ID

ZDB-FIG-260316-80

Publication

Wang et al., 2026 - Zebrafish PRL-3 Regulates Yolk Syncytial Layer Integrity and Actomyosin Contractility During Epiboly

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Figure 2

Zebrafish PRL-3 knockdown impairs epiboly progression. Representative bright-field images showing developmental staging of zebrafish embryos injected with 4 ng control morpholino (MO) (N = 88) or zfPRL-3 MO (N = 60) and examined at the indicated time points. Percentages indicate the proportion of embryos in each group that were scored as the indicated developmental stage at each time point. (A–E) Control MO–injected embryos progressed normally: (A) 1k-cell stage (3 h post fertilization; hpf), (B) sphere (4 hpf), (C) dome (5 hpf), (D) shield (6 hpf), and (E) ~75% epiboly (8 hpf). (F–J) zfPRL-3 morphants showed delayed progression, remaining at earlier stages at later time points: embryos were at the 1k-cell stage at 3 hpf (F), remained at the sphere stage at 4–5 hpf (G,H), and were only at the dome stage at 6–8 hpf (I,J). Scale bars = 250 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-ptp4a3a
Knockdown Reagent:	MO1-ptp4a3a
Observed In:	epiboly
Stage Range:	1k-cell to 75%-epiboly

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.