Fig 7

Summary model indicating putative roles for elf3 in zebrafish. elf3 has roles in mediating host transcriptional responses to the microbiota as well as transcriptional programs important for microbe-independent physiologic functions. In response to microbes, elf3 mediates the upregulation of genes involved in immune and defense response as well as hematopoietic marker genes while mediating the downregulation of genes with roles in abiotic responses (e.g., circadian rhythm) and organic acid metabolism. Additionally, elf3 mutation results in the upregulation of transcriptional programs like mRNA stability, proline metabolism, and response to stress and the downregulation of pyruvate and glycerophospholipid metabolism genes in a microbe-independent manner. elf3 mutation has significant consequences for the survival of adult zebrafish; however, it remains unclear if this effect is related to the role of elf3 in host-microbiota interactions. All the putative roles for elf3 indicated in this model could be direct or indirect.