FIGURE

Fig. 1

ID

ZDB-FIG-251016-86

Publication

Park et al., 2025 - Lego Self-Assembly Model of Zebrafish RGB Cone Pentamer Formation: Unique Role of Crumbs2b in Cone Coalescence via Planar Orientational Cell Adhesions

Other Figures

All Figure Page

Back to All Figure Page

Fig. 1

crb2bsa21178 mutation eliminates Crb2b expression in the retina with no gross defects. (A) The position of crb2bsa21178 mutation and the Zou anti-Crb2b antibody binding site in the extracellular domains of the Crb2b-lf and Crb2b-sf. The EGF-like, laminin A/G-like transmembrane motifs are illustrated as shaded boxes. (B) The strategy to genotype wild-type (WT) and crb2bsa21178 mutant (–/–) fish by PCR and Hind III digestion. (C) crb2bsa21178 mutant fish showed no apparent differences in body shape at 3 dpf and adulthood compared to the wild-type. (D) Crb2b immunostaining signals (red, arrowheads) were eliminated in crb2bsa21178 homozygous mutant retina at 5 dpf. The photoreceptor layer (photo), inner nuclear layer (INL), ganglion cell layer (GCL), lens, and optic nerve (ON) were revealed by phalloidin staining of actin and DAPI staining of the cell nuclei.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Invest. Ophthalmol. Vis. Sci.