FIGURE

Fig. 4

ID
ZDB-FIG-250416-90
Publication
Jia et al., 2025 - Activation of prep expression by Tet2 promotes the proliferation of bipotential progenitor cells during liver regeneration
Other Figures
All Figure Page
Back to All Figure Page
Fig. 4

Prep regulates the proliferation of bipotential progenitor cells. (A) Single-section confocal microscope images showing anti-PCNA and anti-2F11 antibody staining of the regenerated livers of WT siblings and Prep−/− at BT, R0h, R8h, R24h and R48h. (B) Ratio of PCNA+ cells to 2F11+ cells in regenerated livers from A. The probability of PCNA+/2F11+ in regenerating livers was significantly reduced in Prep−/− compared with WT. (C) Single-section confocal microscope images showing anti-PCNA and anti-2F11 antibody staining of the regenerated livers from the DMSO and PRA treatment groups at BT, R0h, R8h, R24h and R48h. (D) Ratio of PCNA+ cells to 2F11+ cells in regenerated livers from C. (E) Single-section confocal microscope images showing anti-PCNA and anti-2F11 antibody staining of the regenerated livers of WT siblings and Tg (hsp701: Prep) at BT, R0h, R8h, R24h and R48h. (F) Ratio of PCNA+ cells to 2F11+ cells in regenerated livers from E. ns, not significant; *P<0.05, ***P<0.001 (two-tailed post hoc test). Data are mean±s.e.m. Scale bars: 75 µm.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development