FIGURE

Fig. 8

ID

ZDB-FIG-250327-46

Publication

Berlingerio et al., 2025 - Targeting oxidative stress-induced lipid peroxidation enhances podocyte function in cystinosis

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Fig. 8

Combinatorial treatment with cysteamine and MitoTEMPO or liproxstatin-1 decreases 4-HNE protein expression in cystinosis podocytes. (a, b) Left panel: Representative western blot image of 4-hydroxynonenal (4-HNE)-conjugated protein levels in a. CTNS−/−#1 and b. CTNS−/−#2 treated with 100 µM cysteamine, 10 µM MitoTEMPO, 100 µM cysteamine + 10 µM MitoTEMPO, 10 µM liproxstatin-1, or 100 µM cysteamine + 10 µM liproxstatin-1 for 48 h. β-Actin was used as a loading control. Right panel: Quantification of 4-HNE protein expression normalized to β-Actin. (n = 4 biological experiments, n = 1 technical replicate) Statistical analysis: one-sample t-test, with WT set as the reference. AU = arbitrary units. Each dot represents a biological experiment

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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