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Fig. 2

ID

ZDB-FIG-250116-17

Publication

Lovely, 2024 - Bone Morphogenetic Protein signaling pathway - ethanol interactions disrupt palate formation independent of gata3

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Fig. 2

Upregulation of GATA3 does not rescue ethanol-induced palate defects in bmp4 mutant larvae. Comparison of palate defects in non-heat shocked control and ethanol-treated bmp4 mutant larvae to heat shocked control and ethanol-treated bmp4 mutant larvae. Ethanol exposure results in over 20 % of palate defects in bmp4 mutant larvae. Heat shock induced, upregulation of GATA3 does not rescue ethanol induced palate defects in bmp4 mutant larvae. Percent of phenotypes were quantified and compared for untreated and ethanol-treated larvae for each Bmp component using (two-way ANOVA, F = 57.77, p < 0.0001; pairwise comparisons **** = p < 0.0001, ** = p < 0.005). “n” for each treatment group listed in Table 4.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	bmp4^st72/st72 bmp4^st72/st72; au34Tg
Conditions:	chemical treatment by environment: ethanol chemical treatment by environment: ethanol, heat shock
Observed In:	neurocranial trabecula
Stage:	Day 5

Phenotype Detail

Acknowledgments

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Reprinted from Reproductive toxicology (Elmsford, N.Y.), 131, Lovely, C.B., Bone Morphogenetic Protein signaling pathway - ethanol interactions disrupt palate formation independent of gata3, 108754, Copyright (2024) with permission from Elsevier. Full text @ Reprod. Toxicol.