Fig. 6
- ID
- ZDB-FIG-240307-10
- Publication
- Glessner et al., 2023 - Biliary atresia is associated with polygenic susceptibility in ciliogenesis and planar polarity effector genes
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Protein-protein interaction network of 149 highly connected nodes with ≥6 interactions identified in integrative analysis of RNA-sequencing and GWAS genes. Target genes were upregulated in the BA transcriptome and selected from among 1,389 genes including 102 BA-associated CPLANE genes and genes in proximity to SNPs with significant differences between 811 BA cases and 4,654 controls (p <0.0001) and the first neighbors of these gene sets in the STRING database. These genes were present in significant gene ontology biological processes (adjusted p value <0.01). Node colors indicate the biological processes associated with the genes. Rectangular outlines identify CPLANE genes. Details for 149 network genes and associated pathways are provided in Tables S12-S15. BA, biliary atresia; GWAS, genome-wide association study. BA, biliary atresia, CPLANE, ciliogenesis and planar polarity effector; GWAS, genome-wide association study; SNPs, single nucleotide polymorphisms. |
Reprinted from Journal of hepatology, 79(6), Glessner, J.T., Ningappa, M.B., Ngo, K.A., Zahid, M., So, J., Higgs, B.W., Sleiman, P.M.A., Narayanan, T., Ranganathan, S., March, M., Prasadan, K., Vaccaro, C., Reyes-Mugica, M., Velazquez, J., Salgado, C.M., Ebrahimkhani, M.R., Schmitt, L., Rajasundaram, D., Paul, M., Pellegrino, R., Gittes, G.K., Li, D., Wang, X., Billings, J., Squires, R., Ashokkumar, C., Sharif, K., Kelly, D., Dhawan, A., Horslen, S., Lo, C.W., Shin, D., Subramaniam, S., Hakonarson, H., Sindhi, R., Biliary atresia is associated with polygenic susceptibility in ciliogenesis and planar polarity effector genes, 1385-1395, Copyright (2023) with permission from Elsevier. Full text @ J. Hepatol.