FIGURE

Fig. 5

ID

ZDB-FIG-240226-16

Publication

Baek et al., 2022 - Single-cell transcriptome analysis reveals three sequential phases of gene expression during zebrafish sensory hair cell regeneration

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

Ribosome biogenesis, spliceosome, HC genes, Wnt, Notch, and cell-cycle genes are enriched 3–10 h after HC death (A) Heatmap of the average expression of selected genes upregulated in several cell types at 3–10 h after HC death. (B–E) Heatmaps of the average expression of selected cell-type-specific genes upregulated 3–10 h after HC death. (F) ISH images of nop58, dla, and mcm3 in neuromasts during HC regeneration. Scale bar, 20 μm. (G–K) Dot plots displaying the average expression per time point of (G) ribosome biogenesis, (H) spliceosome, (I) HC lineage, (J) Wnt signaling, and (K) cell-cycle genes. The dot size shows the percentage of cells that express the gene. (L) Cell-cycle genes by cell-type enrichment. Amplifying SCs are omitted. (M–O) Gene enrichment term analysis of upregulated and downregulated genes at (M) 3 h, (N) 5 h, and (O) 10 h after HC death compared with all other time points.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Cell, 57(6), Baek, S., Tran, N.T.T., Diaz, D.C., Tsai, Y.Y., Acedo, J.N., Lush, M.E., Piotrowski, T., Single-cell transcriptome analysis reveals three sequential phases of gene expression during zebrafish sensory hair cell regeneration, 799-819.e6, Copyright (2022) with permission from Elsevier. Full text @ Dev. Cell