FIGURE

Fig 5

ID

ZDB-FIG-231118-5

Publication

Veen et al., 2023 - Her6 and Prox1a are novel regulators of photoreceptor regeneration in the zebrafish retina

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Fig 5

Loss of Prox1a decreases PR production at 120 hours post-ablation.

(A-D”) Knockdown of Prox1a via morpholino (MO) in adult retina during regeneration does not significantly affect percentage of PCNA+ (pink) proliferative Müller glia (marked by GFAP, green) following prox1a MO (72hpa n = 13, 18.7 ±03.692, 120hpa n = 10, 29.84 ±4.805) compared to SC (72hpa n = 8, 26.82 ±7.14, 120 hpa n = 9, 29.37 ±4.408), quantified in E. (F-I’) Knockdown of Prox1a resulted in a significant reduction of cone photoreceptors as marked by zpr1 (72hpa n = 15, 7.312 ±1.806, 120hpa n = 12, 14.05 ±2.539) compared to SC (72hpa n = 8, 25.98 ±8.962, 120 hpa n = 9, 35.4 ±7.836) in the ONL, quantified in J. DAPI labels cell nuclei (cyan). Data are represented as mean ± SEM. *p < 0.05. Scale bars: 50 μm. (K) Summary of regenerative time course following Prox1 MO knockdown showing reduction in mature regenerated photoreceptors.

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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