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ZDB-FIG-231108-42

Publication

Chang et al., 2023 - Zebrafish facilitate non-alcoholic fatty liver disease research: Tools, models and applications

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Fig. 1

Liver morphology and NAFLD progression in humans and zebrafish. (A) Zebrafish have a similar anatomy of the digestive system compared with humans. Tissue pathological processes can be studied for metabolic associated liver diseases. (B) The progression of NAFLD in humans and zebrafish. Lipid accumulation in the liver caused by obesity, insulin resistance and other factors leads to steatosis. Increased inflammation and oxidative stress promote NASH, and immune escape and fibrosis further lead to liver cirrhosis and even HCC. HCC, hepatocellular carcinoma; NAFLD, non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis.

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