PUBLICATION
Zebrafish facilitate non-alcoholic fatty liver disease research: Tools, models and applications
- Authors
- Chang, C., Li, H., Zhang, R.
- ID
- ZDB-PUB-230501-41
- Date
- 2023
- Source
- Liver international : official journal of the International Association for the Study of the Liver 43(7): 1385-1398 (Review)
- Registered Authors
- Zhang, Ruilin
- Keywords
- hepatotoxicity, inflammation, lipid metabolism, non-alcoholic fatty liver disease, zebrafish
- MeSH Terms
-
- Animals
- Carcinoma, Hepatocellular*/pathology
- Disease Models, Animal
- Liver/pathology
- Liver Neoplasms*/pathology
- Mammals
- Non-alcoholic Fatty Liver Disease*/pathology
- Zebrafish
- PubMed
- 37122203 Full text @ Liver Int.
Citation
Chang, C., Li, H., Zhang, R. (2023) Zebrafish facilitate non-alcoholic fatty liver disease research: Tools, models and applications. Liver international : official journal of the International Association for the Study of the Liver. 43(7):1385-1398.
Abstract
Non-alcoholic fatty liver disease (NAFLD) has become an increasingly epidemic metabolic disease worldwide. NAFLD can gradually deteriorate from simple liver steatosis, inflammation and fibrosis to liver cirrhosis and/or hepatocellular carcinoma. Zebrafish are vertebrate animal models that are genetically and metabolically conserved with mammals and have unique advantages such as high fecundity, rapid development ex utero and optical transparency. These features have rendered zebrafish an emerging model system for liver diseases and metabolic diseases favoured by many researchers in recent years. In the present review, we summarize a series of tools for zebrafish NAFLD research and the models established through different dietary feeding, hepatotoxic chemical treatments and genetic manipulations via transgenic or genome editing technologies. We also discuss how zebrafish models facilitate NAFLD studies by providing novel insights into NAFLD pathogenesis, toxicology research, and drug evaluation and discovery.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping